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14 Cards in this Set
- Front
- Back
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What diagnostic test would you order for multiple sclerosis
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MRI
Cerebral or Spinal plaques |
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possible causes of MS
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Possible infectious stimulus
Epstien Barre Virus |
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Positive Prognostic factors of MS
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More benign in women
earlier age of dx relapsing form of disease |
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symptoms of ms
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Cognitive
Paroxysmal: trigeminal neuralgia, pain, paresthesia, weakness, tonic seizure, dysarthia and ataxia, pruritus, diplopia, akinesia, dystonia TWS PAD PAD PD |
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treatment of MS
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Rebif/avonex
anticonvulsants NSAID Benzodiazepine Modafinil Corticosteroids Interferon Immunosupprestents |
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pathophysiology of Myasthenia gravis
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autoimmune disease affecting blockage or neuromuscular junction
auto antibodies against acetylcholine receptors some have thymic abnormalities some have SLE RA Graves |
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the cardinal feature of mG is
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degree of muscle weakness increases with exercise and improves with rest.
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clinical presentation of mg
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Bulbar muscles affected ie myasthenic snarl, nasal speech, loss of consanants, chewing and swallowing difficulties, head falls foward
Limb and trunk muscles Myashenic crises of respiratory muscles may require intubation |
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What is a tensilon test and when is it used?
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Diagnostic for MG. Test is positive if there is a temporary improvement in muscle strength.
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medication for MG
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The standard medication is anticholinestgerase : Pyridostigmine (mestinon) 30 mg q6
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Treatment for mg
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thymectomy (controversial)
immunosuppresive agents corticosteroids azathioprine cyclosporine (monitor kidney and htn) |
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in the case of mg crises what is the therapy
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plasmapheresis 2-4 l 2-3x/wkx2weeks
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Treatment for MG crises
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1. Respiratory assistance, pulmonary phsiotherapy/ Intubation
2. Stop Anticholenesterase meds 3. Treat underlying infection with antibiotics 4.Plasmapharesis IAAP |
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Describe Gullian Barre syndrom
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idiopathic acute inflammatory demylinateing polyneuropathy
Acute onset, starts distal progressive muscle weakness |
