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100 Cards in this Set
- Front
- Back
3 Types of muscles
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1. smooth 2. skeletal/striated 3. cardiac
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3 Types of muscles
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1. smooth 2. skeletal/striated 3. cardiac
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smooth muscle
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internal organs
long/thin cells |
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smooth muscle
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internal organs
long/thin cells |
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skeletal/striated muscle
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main movers
long cylindrical fibers with stripes |
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skeletal/striated muscle
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main movers
long cylindrical fibers with stripes |
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cardiac muscle
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heart
fused fibers contract together |
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cardiac muscle
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heart
fused fibers contract together |
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muscles are composed of
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fibers
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muscles are composed of
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fibers
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each fiber in the muscle is innervated by
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one motor neuron
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one motor neuron innervates
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many fibers
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motor unit is the
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smallest functional unit
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neuron meets fiber at
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neuromuscular junction
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acetylcholine excites
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muscle, causing contraction
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antagonistic muscles work in
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concert
flexors vs extensors (i.e. biceps and triceps) |
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myasthenia gravis is an
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autoimmune disorder
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myasthenia gravis has antibodies against
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ACh receptors
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symptoms of myasthenia gravis
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progressive weakness
rapid fatigue of skeletal muscles |
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myasthenia gravis has fewer
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ACh receptors
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myasthenia gravis undergoes
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morphological changes at synapse
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myasthenia gravis is responsible for the action of
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acetylcholinesterase
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myasthenia gravis is responsible for the action of acetylcholinesterase means
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a lower likelihood ACh reaches enough receptors
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treatment of myasthenia gravis
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immunosuppressants
acetylcholinesterase inhibitors |
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fast-twitch fibers are used during
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sprinting
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fast-twitch fibers generate
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greatest force
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fast-twitch fibers fatigue
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rapidly
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fast-twitch fibers are
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anaerobic (do not require oxygen)
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fast-twitch fibers contract and relax
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rapidly
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slow-twitch fibers have a longer
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contraction time
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slow-twitch fibers are
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aerobic (require oxygen)
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slow-twitch fibers are resistant to
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fatigue
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slow-twitch fibers generate much less
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force
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slow-twitch fibers are used during
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walking
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proprioceptors are sensitive to
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position and movement of muscles
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proprioceptors detect
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muscular stretch and tension
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proprioceptors allow spinal cord to
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adjust signal
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two primary types of proprioceptors are
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muscle spindles, and golgi tendon organs
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muscle spindles are parallel
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to muscles
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muscle spindles senses
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stretch
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muscle spindles order
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muscle stretched-->signals to motor neuron in spinal cord-->muscle contraction
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negative feedback of muscle stretched
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stretch causes contraction
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muscle spindles stimulate
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STRETCH REFLEX (knee-jerk reflex)
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golgi tendon organs are located
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in tendons (connecting muscles to bone)
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golgi tendon organs senses
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tension
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golgi tendon organs order
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vigorous muscle contraction-->signal to spinal cord inhibitory interneurons-->inhibit motor neuron(inhibits contraction)
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negative feedback for golgi tendon organs
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tension causes muscle relaxation; a negative feedback system that regulates muscle tension; decreases the activation of a muscle when exceptionally large forces are generated and this way protects the muscles integrity
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golgi tendon organs protects against
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too vigorous a contraction
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reflexes are what kind of responses to stimuli?
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consistent, automatic
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whats ann example of a reflex?
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babinski reflex (if you stroke the sole of the foot, the infant extends the big toe and fans the others)
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allied reflexes occur
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together/illicit each other
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ballistic movements are executed as
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a whole
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ballistic movements cannot be
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corrected/not sensitive to feedback
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whats an example of a ballistic movement?
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reflexes
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most movements are subject to
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feedback
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motor programs are neural circuits that
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produce fixed sequence of movements
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neural circuits are predictable
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motor sequences
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there are two types of neural circuits
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built-in ( rodent grooming, yawning) vs learned (gymnast, pianist)
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neural circuits are produced by
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Central Pattern Generators or other mechanisms
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central pattern generators are natural
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mechanisms that generate rhythmic motor patterns (wet dog shake, wing flapping in birds, licking in rodents)
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the forebrain consists of
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the cortex and the basal ganglia
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the midbrain consists of
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the substantia nigra, the red nucleus, and the reticular formation
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major motor areas of the hindbrain are
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cerebellum, reticular formation and vestibular nucleus
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primary motor cortex is involved with
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coordinated movements in several muscles leading to a specific outcome
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posterior parietal cortex is involved with
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coordinating movement through the environment based on visual input
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prefrontal cortex is involved with
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planning movement
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premotor cortex is involved with
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planning movement
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supllementary cortex is involved with
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preparation for rapid sequences of movement
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what are two primary motor pathways to the spinal cord?
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dorsolateral tract and ventromedial tract
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posterior parietal cortex is involved with
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coordinating movement through the environment based on visual input
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prefrontal cortex is involved with
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planning movement
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premotor cortex is involved with
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planning movement
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supllementary cortex is involved with
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preparation for rapid sequences of movement
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what are two primary motor pathways to the spinal cord?
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dorsolateral tract and ventromedial tract
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the dorsolateral tract carries
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axons from primary motor cortex and surrounding areas and from the red nucleus (midbrain) to spinal interneurons controlling spinal motor neurons
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dorsolateral tract crosses over
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to the contralateral side at the pyramids in the ventral portion of the anterior medulla (also referred to as pyramidal tract)
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the dorsolateral tract courses down the
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dorsolateral portion of the white matter of the spinal cord
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the dorsolateral tract controls
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movements of distal limbs including hands fingers and toes
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the ventromedial tract carries
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axons from primary motor cortex and many other cortical areas. Axons from the vestibular nucleus, tectum, and reticular formation also contribute. These axons synapse on spinal interneurons (and some motor neurons) controlling spinal motor neurons
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in the ventromedial tract some axons
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cross and others dont, providing bilateral innervation
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the ventromedial tract courses down
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the ventromedial portion of the white matter of the spinal cord
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the ventromedial tract controls movements of
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proximal limbs and axial musculature including neck, shoulders and trunk.
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the ventromedial tract is involved with
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with gross movements and posture
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the cerebellum contains
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more neurons than the rest of the structures of the brain combined
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the cerebellum is involved in
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control of rapid ballistic movements(including saccades), timing and establishment of new motor programs
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cerebellar damage affects
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tapping a rhythm, athletics, speaking and writing, typing, playing musical instruments, hand clapping (and other basic repetitive movements), simple saccades, finger to nose test
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the basal ganglia consists of
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caudate nucleus, putamen, globus pallidus
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caudate nucleus is primarily
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input area. receives info from sensory areas of the thalamus and cortex. also receives important dopaminergic projection from the substantia nigra in the midbrain
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putamen is
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the same as the caudate nucleus
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the globulus pallidus is primarily
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an output area. it sends info to the thalamus, which in turn sends info to motor and prefrontal cortex. it also sends information to midbrain
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what is the role of the basal ganglia?
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organization of action sequences into chunks, inhibition of specific motor responses
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some of the roles of the basal ganglia can be understood by
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examining the consequences of parkinsons disease
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prakinsons disease is the
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degeneration of the dopaminergic neurons in the substantia nigra projecting to the caudate nucleus and putamen
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parkinsons affects
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rigidity, muscle tremors, slow movements, difficulty initiating movement, sometimes associated with depression, sometimes associated with cognitive deficits, affects 1 in 100 above age 50
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possible causes of parkinsons disease
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early onset (before 50) has a genetic predisposition, possible environmental influences (toxins)
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parkinsons and cigarette smoke and coffee
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helps!
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treatment of parkinsons disease
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L-Dopa
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L-Dopa
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unlike dopamine, L-Dopa can cross blood-brain barrier where it is absorbed by neurons and can increase dopamine production
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L-Dopa can't restore
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degenerated neurons, effectiveness declines as the disease progresses; side effects are a problem
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other possible treatments of parkinsons
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antioxidant drugs to decrease further damage; Dopaminergic agonists that can cross blood-brain barrier; glutamate or adeonsine antagonists; drugs that block certain calcium channels abundant in elderly brains; neurotrophins to promote growth and survival of neurons; drugs that decrease aptosis; drugs that stimulate cannabinoid receptors; inactivating electrical stimulation of globus pallidus; fetal tissue transplants
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