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100 Cards in this Set

  • Front
  • Back
3 Types of muscles
1. smooth 2. skeletal/striated 3. cardiac
3 Types of muscles
1. smooth 2. skeletal/striated 3. cardiac
smooth muscle
internal organs
long/thin cells
smooth muscle
internal organs
long/thin cells
skeletal/striated muscle
main movers
long cylindrical fibers with stripes
skeletal/striated muscle
main movers
long cylindrical fibers with stripes
cardiac muscle
heart
fused fibers contract together
cardiac muscle
heart
fused fibers contract together
muscles are composed of
fibers
muscles are composed of
fibers
each fiber in the muscle is innervated by
one motor neuron
one motor neuron innervates
many fibers
motor unit is the
smallest functional unit
neuron meets fiber at
neuromuscular junction
acetylcholine excites
muscle, causing contraction
antagonistic muscles work in
concert
flexors vs extensors
(i.e. biceps and triceps)
myasthenia gravis is an
autoimmune disorder
myasthenia gravis has antibodies against
ACh receptors
symptoms of myasthenia gravis
progressive weakness
rapid fatigue of skeletal muscles
myasthenia gravis has fewer
ACh receptors
myasthenia gravis undergoes
morphological changes at synapse
myasthenia gravis is responsible for the action of
acetylcholinesterase
myasthenia gravis is responsible for the action of acetylcholinesterase means
a lower likelihood ACh reaches enough receptors
treatment of myasthenia gravis
immunosuppressants
acetylcholinesterase inhibitors
fast-twitch fibers are used during
sprinting
fast-twitch fibers generate
greatest force
fast-twitch fibers fatigue
rapidly
fast-twitch fibers are
anaerobic (do not require oxygen)
fast-twitch fibers contract and relax
rapidly
slow-twitch fibers have a longer
contraction time
slow-twitch fibers are
aerobic (require oxygen)
slow-twitch fibers are resistant to
fatigue
slow-twitch fibers generate much less
force
slow-twitch fibers are used during
walking
proprioceptors are sensitive to
position and movement of muscles
proprioceptors detect
muscular stretch and tension
proprioceptors allow spinal cord to
adjust signal
two primary types of proprioceptors are
muscle spindles, and golgi tendon organs
muscle spindles are parallel
to muscles
muscle spindles senses
stretch
muscle spindles order
muscle stretched-->signals to motor neuron in spinal cord-->muscle contraction
negative feedback of muscle stretched
stretch causes contraction
muscle spindles stimulate
STRETCH REFLEX (knee-jerk reflex)
golgi tendon organs are located
in tendons (connecting muscles to bone)
golgi tendon organs senses
tension
golgi tendon organs order
vigorous muscle contraction-->signal to spinal cord inhibitory interneurons-->inhibit motor neuron(inhibits contraction)
negative feedback for golgi tendon organs
tension causes muscle relaxation; a negative feedback system that regulates muscle tension; decreases the activation of a muscle when exceptionally large forces are generated and this way protects the muscles integrity
golgi tendon organs protects against
too vigorous a contraction
reflexes are what kind of responses to stimuli?
consistent, automatic
whats ann example of a reflex?
babinski reflex (if you stroke the sole of the foot, the infant extends the big toe and fans the others)
allied reflexes occur
together/illicit each other
ballistic movements are executed as
a whole
ballistic movements cannot be
corrected/not sensitive to feedback
whats an example of a ballistic movement?
reflexes
most movements are subject to
feedback
motor programs are neural circuits that
produce fixed sequence of movements
neural circuits are predictable
motor sequences
there are two types of neural circuits
built-in ( rodent grooming, yawning) vs learned (gymnast, pianist)
neural circuits are produced by
Central Pattern Generators or other mechanisms
central pattern generators are natural
mechanisms that generate rhythmic motor patterns (wet dog shake, wing flapping in birds, licking in rodents)
the forebrain consists of
the cortex and the basal ganglia
the midbrain consists of
the substantia nigra, the red nucleus, and the reticular formation
major motor areas of the hindbrain are
cerebellum, reticular formation and vestibular nucleus
primary motor cortex is involved with
coordinated movements in several muscles leading to a specific outcome
posterior parietal cortex is involved with
coordinating movement through the environment based on visual input
prefrontal cortex is involved with
planning movement
premotor cortex is involved with
planning movement
supllementary cortex is involved with
preparation for rapid sequences of movement
what are two primary motor pathways to the spinal cord?
dorsolateral tract and ventromedial tract
posterior parietal cortex is involved with
coordinating movement through the environment based on visual input
prefrontal cortex is involved with
planning movement
premotor cortex is involved with
planning movement
supllementary cortex is involved with
preparation for rapid sequences of movement
what are two primary motor pathways to the spinal cord?
dorsolateral tract and ventromedial tract
the dorsolateral tract carries
axons from primary motor cortex and surrounding areas and from the red nucleus (midbrain) to spinal interneurons controlling spinal motor neurons
dorsolateral tract crosses over
to the contralateral side at the pyramids in the ventral portion of the anterior medulla (also referred to as pyramidal tract)
the dorsolateral tract courses down the
dorsolateral portion of the white matter of the spinal cord
the dorsolateral tract controls
movements of distal limbs including hands fingers and toes
the ventromedial tract carries
axons from primary motor cortex and many other cortical areas. Axons from the vestibular nucleus, tectum, and reticular formation also contribute. These axons synapse on spinal interneurons (and some motor neurons) controlling spinal motor neurons
in the ventromedial tract some axons
cross and others dont, providing bilateral innervation
the ventromedial tract courses down
the ventromedial portion of the white matter of the spinal cord
the ventromedial tract controls movements of
proximal limbs and axial musculature including neck, shoulders and trunk.
the ventromedial tract is involved with
with gross movements and posture
the cerebellum contains
more neurons than the rest of the structures of the brain combined
the cerebellum is involved in
control of rapid ballistic movements(including saccades), timing and establishment of new motor programs
cerebellar damage affects
tapping a rhythm, athletics, speaking and writing, typing, playing musical instruments, hand clapping (and other basic repetitive movements), simple saccades, finger to nose test
the basal ganglia consists of
caudate nucleus, putamen, globus pallidus
caudate nucleus is primarily
input area. receives info from sensory areas of the thalamus and cortex. also receives important dopaminergic projection from the substantia nigra in the midbrain
putamen is
the same as the caudate nucleus
the globulus pallidus is primarily
an output area. it sends info to the thalamus, which in turn sends info to motor and prefrontal cortex. it also sends information to midbrain
what is the role of the basal ganglia?
organization of action sequences into chunks, inhibition of specific motor responses
some of the roles of the basal ganglia can be understood by
examining the consequences of parkinsons disease
prakinsons disease is the
degeneration of the dopaminergic neurons in the substantia nigra projecting to the caudate nucleus and putamen
parkinsons affects
rigidity, muscle tremors, slow movements, difficulty initiating movement, sometimes associated with depression, sometimes associated with cognitive deficits, affects 1 in 100 above age 50
possible causes of parkinsons disease
early onset (before 50) has a genetic predisposition, possible environmental influences (toxins)
parkinsons and cigarette smoke and coffee
helps!
treatment of parkinsons disease
L-Dopa
L-Dopa
unlike dopamine, L-Dopa can cross blood-brain barrier where it is absorbed by neurons and can increase dopamine production
L-Dopa can't restore
degenerated neurons, effectiveness declines as the disease progresses; side effects are a problem
other possible treatments of parkinsons
antioxidant drugs to decrease further damage; Dopaminergic agonists that can cross blood-brain barrier; glutamate or adeonsine antagonists; drugs that block certain calcium channels abundant in elderly brains; neurotrophins to promote growth and survival of neurons; drugs that decrease aptosis; drugs that stimulate cannabinoid receptors; inactivating electrical stimulation of globus pallidus; fetal tissue transplants