Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
PNS
|
craniosacral
acH long pre short post ganglia near target organ |
|
|
SNS
|
long post
short pre ganglia near spinal chord norepinephrine adrenal medulla control predominantly direct stiumlation |
|
|
Cromaffin cells
|
epi/norepi
(80/20) |
|
|
adrenergic receptors
|
alpha 1 2
beta 1 2 |
|
|
strength of effector resposne
|
saturation versus clearing
|
|
|
synthesis of NE
|
Tyrosine-Ldopa-dopamine-norepinephrine
|
|
|
Cholingeric receptors
|
Muscarinic
Nicotinic |
|
|
Muscarninc
|
M1-M5
|
|
|
Ach from
|
Acetyl CoA and choline
|
|
|
only PNS innervation
|
lacrimal glands
nasopharyngeal glands |
|
|
only SNS innervation
|
blood vessels
spleen sweat glands |
|
|
Both adrenergic and muscarinic use
|
G protein coupled receptors
|
|
|
GPCR
|
GTP binded protein in membrane
close to receptor 3 subunits (A B gamma) GDP bound when no receptor three types Gs Gl Gq by dif alpha subunits |
|
|
GPCR activation
|
GDP to GTP
alpha seperates alpha goes to somewhere else in mmembrane and activates it often enyzme that catalyzes second messenger GTP hydrolysis restores |
|
|
NE or EPI on beta 1 and 2
|
alpha subunit activates (alpha s) activates
adenylyl cyclase cAMP PKA |
|
|
NE or Epi on alpha 1
|
alphaq activates phospholipase C
phospholipase C splits PIP3 into diacylglycerol and inositol triphosphate 3 DAG activates protein kinase C IP3 releases ca++ which activates protein kinase C |
|
|
Ne or Epi on alpha 2
|
Gi type
alpha i binds to adenylyl cyclase INHIBITS it lowers cAMP |
|
|
GPCRS muscarinic
|
Gq
Gi |
|
|
GPCR muscarinic Gq
|
phospholipase C
IP3 DAG |
|
|
GPCR muscarinic Gi
|
alpha binds to adenylyl cyclase
lowers cAMP beta gamme binds to K+ in heart nodal tissue...increases K+ conductance |
