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25 Cards in this Set
- Front
- Back
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Monoclonal Abs
-ximab -zumab -umab |
-chimeric (Rituximab)
-humanized (natalizumab) -fully human (adalimumab) |
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Receptor fusion proteins
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-cept (abatacept)
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In RA Abatacept binds to ____ to prevent ____ activation
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CD80/86
T cell activation |
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Most widely used RA drug
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methotrexate
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Leflunomide blocks
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de novo pyrimidine synthesis
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Pro-inflammatory cytokines
TNF_ IL IL IL IL |
TNFa
IL-1B IL-6 IL-12 IL18 |
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Anti-inflammatory cytokines
TNF_ GM_ IL ____ TNF ____ IL1 ___ |
TGFB
GM-CSF IL-10 Soluble TNF receptor IL-1 receptor antagonist |
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DMARDs
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Disease modifying anti-rhuematic drugs
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Scleroderma hallmarks (3)
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1)Abnormal immune response
2)Vascular Abnormalities 3)Fibrosis of skin |
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Scleroderma HLA
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HLA-DQ7
HLA-DR5 |
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Scleroderma specific autoimmune issues
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Anti-topoisomerase I
Anti-RNA polymerase Anti-centromere (CREST) |
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CREST in Scleroderma stands for __
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Calcinosis
Raynaud’s Esophageal dysmotility Sclerodactyly Telangectasias |
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Vasospasm
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aka Raynaud’s
reversible distal digital artery narrowing and occlusion |
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Normally undetectable ____ is found increased in skin, lungs, vasculature in scleroderma
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PDGF
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Endothelial cells produce ___ which makes ___ produce ___
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endothelin
fibroblasts TGFB |
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Pro- fibrotic cytokines
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IL4 (T-cells)
IL1 (fibroblasts) |
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____ is leading cause of death in scleroderma
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Lung Disease
-Interstitial lung disease Pulmonary hypertension |
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Sjogren’s syndrome is a ____ ____ disease
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autoimmune exocrinopathy
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Anti __ and anti___ found in Sjogren’s
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Anti-Ro
Anti-La |
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Sicca
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diminished lacrimal and salivary secretions
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Salivary epithelial cells in Sjogren’s function more like ___
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APCs
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In Sjogren’s salivary epithelial cells produce ___ and B cells produce ___
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Bax (pro-apoptotic)
BCLX1 (anti-apoptotic) |
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Schirmer’s eye test
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measures tear production
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Causes of Sjogren’s (3)
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Parenchymal loss (apoptosis)
Anti-M3r Abs Cholinesterase increases Ach breakdown |
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Sjogren’s can progress into _____ lymphomas after many years
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MALT (marginal zone)
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