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54 Cards in this Set

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  • Back
Define mood
Description of one's internal emotional state
What is another name for mood disorder?
Affective disorder
What is the difference between a mood episode and mood disorder?
Mood episode are distinct periods of time when abnormal mood is present; mood disorder are patterns of mood episodes
What are the types of mood episodes?
1) Major depressive
2) Manic
3) Hypomanic
4) Mixed episode
What are the types of mood disorders?
1) Major depressive disorder
2) Bipolar I & II disorder
3) Dysthymic disorder
4) Cyclothymic disorder
What are the DSM-IV criteria to be a major depressive episode?
Must have at least 5 of the following during the same 2 week period...(must include anhedonia or depressed mood)
SIG E CAPS

D - depressed mood
S - sleep disturbances
I - interest (anhedonia)
G - guilt or worthlessness
E - energy or fatigue
C - concentration, can't think
A - appetite up or down
P - psychomotor agitation or retardation
S - suicidal ideation

*must cause social or occupational impairment
What are the DSM-IV criteria to be a manic episode?
Must have at least 3 of the following for at least 1 week...
DIG FAST

D - distractability
I - insomnia
G - grandiosity
F - flight of ideas
A - activity/agitation increased
S - speech pressured
T - thoughtlessness

*must cause social or occupational impairment
What is a manic episode?
A condition characterized by elevated or irritable (easily annoyed) mood lasting at least 1 week
Is a manic episode a psychiatric emergency? Why?
Yes because severely impaired judgment makes patient dangerous to self and others
What is a mixed episode?
Episode that meets the criteria of both manic and major depressive episode for at least 1 week
*psychiatric emergency
What is the predominant mood in patients with mixed episodes?
Irritable mood
Does lithium work well for mixed episodes?
Patients with mixed episodes have a poorer response to lithium; anticonvulsants may help
What is a hypomanic episode?
Condition characterized by period of elevated or irritable mood; lower of degree of impact on functioning than mania
What is the difference between a manic and hypomanic episode?
Mania - causes severe impairment in social/occupational functioning, may require hospitalization, may have psychotic symptoms
Hypomania - no marked impairment in social/occupational functioning, no hospitalization, no psychotic features
What is the DSM-IV criteria for major depressive disorder (MDD)?
At least 1 major depressive episode and no history of manic/hypomanic episode
What is seasonal affective disorder?
Subtype of MDD in which major depressive episodes occur only during winter months (fewer daylight hours)
What is the treatment for seasonal affective disorder?
Light therapy
What are the sleep problems associated with MDD?
1) Multiple awakenings
2) Hard to fall asleep, early morning awakenings
3) Hypersomnia
4) REM affected
What is the triad for seasonal affective disorder?
1) Irritability
2) Hypersomnia
3) Carbohydrate drawing - crave sweets and starchy food
How is serotonin related to depression? How can this be used to treat depression?
Decreased brain levels of serotonin and 5-HIAA (hydroxyindolacetic acid) are found in depressed patients
Drugs that increase the availability of serotonin, NE and dopamine alleviate the symptoms of depression
What are other neuroendocrine abnormalities that are associated with depression?
1) high cortisol
2) thyroid disorders
What psychosocial life event is associated with MDD?
Loss of a parent before age 11
Is there a genetic component to depression?
1st degree relatives are 2-3x more likely to have MDD
Can MDD be associated with psychotic features?
Yes, hallucinations or delusions
What are the different treatment modalities of MDD?
1) Hospitalization
2) Pharmacotherapy
3) Psychotherapy
4) ECT
When is hospitalization indicated for MDD?
If patient at risk for suicide, homicide or unable to care for self
What is the difference btwn all of the antidepressant medications?
All are equally effective but differ in side effect profile; medications take 4 to 8 weeks to work
Describe SSRI's
Selective serotonin reuptake inhibitor - safe, well tolerated, mild side effects; main one is sexual dysfunction
Describe TCA's
Tricyclic antidepressants - overdose is lethal, side effects include anticholinergic effects and can aggravate prolonged QT syndrome
Describe MAOIs
Monoamine oxidase inhibitors, useful for refractory depression
*risk of hypertensive crisis when used with tyramine-rich foods (wine, cheese)
*risk of serotonin syndrome when used in combination with SSRIs; triad of cognitive, autonomic, and somatic effects
Describe stimulants for treating MDD?
For refractory patients, action is rapid, potential for dependence limits its use
Describe ECT for treating MDD?
Electroconvulsive therapy is indicated if patient is unresponsive to pharmacotherapy or patient cannot tolerate pharmacotherapy or rapid reduction of symptoms is desired
*Retrograde amnesia is a common side effect, which usually disappears within 6 months
Describe serotonin syndrome.
1) Autonomic instability
2) Hyperthermia
3) Seizures

autonomic, cognitive, somatic
What type of patients may not be able to tolerate the side effects of antidepressant medications?
Elderly and pregnant woman
What are the unique types of depressive disorders?
1) Melancholic
2) Atypical
3) Catatonic
4) Psychotic
Describe melancholic MDD
Anhedonia, early morning awakenings, psychomotor disturbance, excessive guilt, anorexia
Describe atypical MDD
Hypersomnia, hyperphagia, reacive mood, hypersensitivity to interpersonal rejection
Describe catatonic MDD
Catalepsy (immobility), purposeless motor activity, extreme negativism, bizarre postures, echolalia
Describe psychotic MDD
Characterized by the presence of delusions or hallucinations
What kind of drug is effective in treating atypical MDD?
MAOIs
How do you treat catatonic MDD?
With both antidepressants and antipsychotics
What is the DSM-IV criteria for bipolar I disorder?
Occurence of one manic or mixed episode; between manic episodes there may be other mood episodes but none are required for diagnosis
Can psychotic features be associated with bipolar I disorder?
Yes, always include bipolar I disorder as part of the differential in a psychotic patient
What pharmacotherapy is out there for treatment of bipolar disorder?
1) Lithium - mood stabilizier
2) Anticonvulsants - carbamazepine and valproic acid
3) Atypical antipsychotic - olanzapine
What are other treatment modalities for bipolar disorder?
Psychotherapy and ECT
What is rapid cycling?
Defined by the occurrence of 4 or more mood episodes in 1 year (major depressive, manic, mixed, etc)
What are the side effects of lithium?
A whole list
What is the DSM-IV criteria for bipolar II disorder?
History of major depressive episode and at least one hypomanic episode

*if there has been a full manic episode even in the past, then the diagnosis is not bipolar II disorder, but bipolar I
What is the DSM-IV criteria for dysthymic disorder?
1) Depressed mood for the majority of the time of most days for at least 2 years
2)
C - concentration poor
H - hopelessness
A - appetite up or down
S - sleep up or down
E - energy
S - self-esteem
*person has not been without the above symptoms for > 2 months at a time; NEVER had a manic or hypomanic episode (would be bipolar disorder)
Define double depression?
Patients with MDD with dysthymic disorder during residual periods
Can you have psychotic features with dysthymia?
Delusions or hallucinations are never in patients with dysthymia; consider another diagnosis
What is the mneumonic of dysthymic disorder?
2 years of depression
2 listed criteria
Never asymptomatic for > 2 months
What is the DSM-IV criteria for cyclothymic disorder?
Numerous periods with hypomanic symptoms and periods of depressive symptoms for at least 2 years, never symptom free for > 2 months during those 2 years
What personality disorder is associated with cyclothymic disorder?
Borderline personality disorder