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40 Cards in this Set

  • Front
  • Back
mood
sustained emotion
euphoric
dysphoric
euthymia
mood disorders
sustained elevation or depression in mood that impairs the ability to fxn in society
2 common mood disorders
major depression
bipolar disorder
biogenic amine theory
meds that deplete norepi and serotonin develop depression
dysregulation theory
impaired balance of neurotransmitters not absolute dec or inc in neurotransmitter causes disruption of mood
anhedonia
loss of interest or pleasure
3 types of trmt for depression
psychotherapy
pharmacotherapy
electroconvulsive therapy
3 phases of pharmacotherapy
acute
continuation
maintenance
psychomotor agitation
may benefit fr sedating antidepressant
serotonin syn for cognitive behavioral dysfxn
confusion
hypomania
agitation
serotonin syn for ans dysfxn
diarrhea
shovering
fever
diaphoresis
changes in bp
nv
ser w/drawl syn ans dysfxn
flu like sx
dixxy
light headed
chills nv sleep disturbances
ser syn neuromuscular dysfxn
myoclonus
hyperreflexia
tremor
sz
death
ser w/drawal syn neuromuscular dysfxn
lethargy
myalgia
sensory disturbances (paresthesia)
tricyclic antidepressant -tci
amitruptyline
doxepin
imipramine
trimipramine
protriptyline
nortriptyline
desipramine
MAOIs
phenelzine
isocarboxazid
tranylcypromine
misc agts
amoxapine
maprotiline
bupropion sr
trazodone
tricyclic amines indication
reserved for previous tca responder
nonsuicidal pts
refractory to newer agts
tca moa
nonspecifically target the sertonin and norepi rec

blking the reuptake of ser and norepi
tca adv eff
lower sz threshold and create cardiac conduction abnormalities that may manifest a T wave flattening or prolongation of the QT, PR OR QRS intervals
maoi indication
atypical depression
refractory
atypical depression
hypersomnia
agitation
anxiety
maoi moa
blk the breakdown of biogenic amines by inhibiting the enz monoamine oxidase thus inc the conc of norepi and 5HT in the braine
isocarboxazid
hepatocellular damage
dc therapy with the 1st sign of
hepatic dysfxn
jaundice
bupropion moa
inhibits the reuptake of ser,norepi and dop
bupropion admin
do not give at bedtime
cause agitation and insomnia
trazodone indication
sleep aid for depressed pts w/ insomnia
trazodone moa
inc ser
trazodone adv eff
priapism
sedation
hypotension
nausea
ssri w/ approved indication for depression
fluoxetine
sertraline
paroxetine
citalopram
ssri moa
nonselective inc ser by blking the reuptake
metabolism of ssri
CYP450
venlafaxine moa
inc 5HT, norepi, dop by blking the reuptake of neurotransmitters
nefazodone moa
inc in ser and 5HT rec antagonism
orthostatic hypotension
caused by blkade of alpha 1 adrenergic rec
nefazodone mon eff
potent cytochrome P4503A4 isoenzyme (CYP3A4)inhibitor and will inc the con of meds that rely on CYP3A4 for metabolism
monitor liver fxn
test for nefazodone
mirtazipine moa
inhibits presynaptic alpha 2 adr rec -> inc central conc of norepi and 5HT
mirtazipine selectivity
5HT1

diminish incidence of se (sexual dysfxn, agitation , insomnia)