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40 Cards in this Set
- Front
- Back
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mood
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sustained emotion
euphoric dysphoric euthymia |
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mood disorders
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sustained elevation or depression in mood that impairs the ability to fxn in society
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2 common mood disorders
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major depression
bipolar disorder |
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biogenic amine theory
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meds that deplete norepi and serotonin develop depression
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dysregulation theory
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impaired balance of neurotransmitters not absolute dec or inc in neurotransmitter causes disruption of mood
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anhedonia
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loss of interest or pleasure
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3 types of trmt for depression
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psychotherapy
pharmacotherapy electroconvulsive therapy |
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3 phases of pharmacotherapy
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acute
continuation maintenance |
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psychomotor agitation
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may benefit fr sedating antidepressant
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serotonin syn for cognitive behavioral dysfxn
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confusion
hypomania agitation |
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serotonin syn for ans dysfxn
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diarrhea
shovering fever diaphoresis changes in bp nv |
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ser w/drawl syn ans dysfxn
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flu like sx
dixxy light headed chills nv sleep disturbances |
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ser syn neuromuscular dysfxn
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myoclonus
hyperreflexia tremor sz death |
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ser w/drawal syn neuromuscular dysfxn
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lethargy
myalgia sensory disturbances (paresthesia) |
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tricyclic antidepressant -tci
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amitruptyline
doxepin imipramine trimipramine protriptyline nortriptyline desipramine |
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MAOIs
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phenelzine
isocarboxazid tranylcypromine |
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misc agts
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amoxapine
maprotiline bupropion sr trazodone |
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tricyclic amines indication
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reserved for previous tca responder
nonsuicidal pts refractory to newer agts |
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tca moa
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nonspecifically target the sertonin and norepi rec
blking the reuptake of ser and norepi |
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tca adv eff
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lower sz threshold and create cardiac conduction abnormalities that may manifest a T wave flattening or prolongation of the QT, PR OR QRS intervals
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maoi indication
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atypical depression
refractory |
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atypical depression
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hypersomnia
agitation anxiety |
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maoi moa
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blk the breakdown of biogenic amines by inhibiting the enz monoamine oxidase thus inc the conc of norepi and 5HT in the braine
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isocarboxazid
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hepatocellular damage
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dc therapy with the 1st sign of
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hepatic dysfxn
jaundice |
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bupropion moa
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inhibits the reuptake of ser,norepi and dop
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bupropion admin
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do not give at bedtime
cause agitation and insomnia |
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trazodone indication
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sleep aid for depressed pts w/ insomnia
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trazodone moa
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inc ser
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trazodone adv eff
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priapism
sedation hypotension nausea |
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ssri w/ approved indication for depression
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fluoxetine
sertraline paroxetine citalopram |
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ssri moa
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nonselective inc ser by blking the reuptake
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metabolism of ssri
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CYP450
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venlafaxine moa
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inc 5HT, norepi, dop by blking the reuptake of neurotransmitters
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nefazodone moa
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inc in ser and 5HT rec antagonism
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orthostatic hypotension
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caused by blkade of alpha 1 adrenergic rec
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nefazodone mon eff
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potent cytochrome P4503A4 isoenzyme (CYP3A4)inhibitor and will inc the con of meds that rely on CYP3A4 for metabolism
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monitor liver fxn
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test for nefazodone
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mirtazipine moa
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inhibits presynaptic alpha 2 adr rec -> inc central conc of norepi and 5HT
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mirtazipine selectivity
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5HT1
diminish incidence of se (sexual dysfxn, agitation , insomnia) |
