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10 Cards in this Set
- Front
- Back
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Synthesis of DA, NE, Epi
Include enzymes and locations |
Tyrosine - Tyrosine hydroxylase (rate limiting) -> LDOPA -> DA - DBH (in secretory granule) -> NE - PNMT (in brain and adrenal medulla) -> Epi
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Balance of the (3) mechanisms that terminate the transmission of monoamines
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Reuptake is 60%, diffusion and metabolism are 20% each
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Monoamine Oxidase
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Enzymatic metabolism of monoamines INSIDE neurons
MOA-B = brain MOA-A = PNS |
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COMT
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Enzymatic metabolism of monoamines extracellularly in periphery and centrally
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DA as a co-transmission neuromodulator in ANS
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In renal vasculature works against sympathetic system causing arterioles to dilate to eliminate salt and water (alters the transporters)
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NO as a co-transmission neuromodulator in ANS
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Used as a second messenger with PS ACh binding to Muscarinic receptors produces vasodilation - used to offset sympathetic action
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Neuropeptide neuromodulators that inhibit release of NE through a specific mechanism and the converse action
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Adenosine and/or NPY act via ATP receptors to inhibit NE release
Conversely, NE + α1 receptor inhibits NPY release |
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NE modulation of its own release (2)
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NE + α2 = inhibit NE release
NE + β2 = facilitate NE release |
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Factors that enhance NE release (2)
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AngII AT1, ACh+nicotinic receptors
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Factors that inhibit NE release
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5HT, PGE2, histamine, enkephalin, DA
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