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6 Cards in this Set
- Front
- Back
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cyclin A
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tracks occurance through S-phase
activates protein kinase to drive cell through cycle |
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G1 cyclins
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push cell through cycle
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G1/S cyclins
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1. G1 complexes with s-cyclins
triggers transcription of s-cyclin genes 2. phosphorylates and inactivates SIC and Hct1-allows cell to go throught G1/S |
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SCF+E1+E2
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multi-protein E3 ligase
ubiquinylation proteasomal degration |
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Rb Protein
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1.tumor suppressor protein
G1-Cdk causes the liberation of E2F from the Rb/E2F complex |
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E2F
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gene regulatory protein
active E2F-> initiates transcripiton of the S-phase genes. |
