Module 8: Molecular Cell Biology

Front 1

the theory of multiple mutations in cancer

Back 1

-Basically, cancer arises from an accumulation of mutations, so the fewer of those that arise as time passes, the less the likelihood of a cancer forming. -Second, when we examine the genetic changes seen in abnormally growing cells we find that the genetic changes are not random.
-there are many families in which cancers seem to be more prevalent than in the general population. We believe that they have mutations in genes involved in cancer.

Front 2

oncogenes

Back 2

a growth control gene initially discovered in cancer cells that will result in unregulated cell growth if there is incorrect expression.

Front 3

tumor suppression genes

Back 3

Mutations in tumor suppressor genes produce an inactive protein product, depriving the cell of crucial tools needed to prevent inappropriate growth.

Front 4

relationship between oncogenes and signaling pathways

Back 4

Oncogenes usually code for products of the cell’s signal transduction pathway.