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15 Cards in this Set
- Front
- Back
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ESI |
Electrospray ionization Ionization source |
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MALDI |
Matrix assisted laser desorption ionization Ionization source |
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APCI |
Atmospheric Pressure Chemical Ionization Ionization source |
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APPI |
Atmospheric Pressure Photoionization Ionization source |
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Quadrapole Mass Analyzer |
4 rods - opposing rod pairs connected Ions oscillate based on m/z - ions with specific m/z get through |
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Selectivity/Specificity |
Ability to accurately measure one or more analytes Minimal to no interference |
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Recovery |
% recovery = (extract response / standard response) x 100 High recovery desirable for good sensitivity, but consistency of recovery is more important |
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Accuracy |
Closeness to true value Deviation of mean from true value < 15% LLOQ (lower limit of quantitation) < 20% |
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Precision |
Consistency of values Coefficient of variation < 15% LLOQ < 20% |
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Linearity |
Ability of method to give results directly proportional to amount of analyte R^2 >= 0.999 |
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Range (linear range) |
Range to upper and lower concentrations which can be detected with precision, accuracy, and linearity |
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Limit of Detection |
Lowest analyte concentration differentiable from background noise |
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Limit of Quantitation |
Minimum analyte amount producing acceptable quantitative results |
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Robustness |
The effect that changes in operational parameters have on other properties of method Closely related to reproducibility |
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Stability |
Stability under various conditions Freeze-thaw, short-term room temperature, long term, stock solution stability |
