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4 Cards in this Set
- Front
- Back
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Characteristics of cancer cells |
Persistant proliferation Invasive Metastatic (travel) Immortal Angiogenesis (recruit blood vessels to grow) |
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Cellular growth fraction |
Ration of proliferating cells to cells at rest (G0) |
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Cells with high cellular growth fraction |
Bone Marrow GI Epithelial cells Hair follicles germinal epithelium of testes (gives rise to sperm) |
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Drug resistance mechanisms |
1.decrease drug uptake 2.increase drug efflux --> PGP 3.decrease drug activation (prodrug) 4.reduced target sensitivity, increased cellular (primarily DNA) repair 5.decreased apoptosis |
