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17 Cards in this Set
- Front
- Back
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Sustained release
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Any formulation that releases slowly over period of time
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Controlled release
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Maintains constant drug level in target organs
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Prolonged release
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Not constant, but prolongs therapeutic levels
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Extended release
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Allows reduction in dosing frequency
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Delayed release
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Delays the release based on time or conditions (i.e. pH)
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Repeat action
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2 doses: one immediate and one delayed
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Targeted release
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Targeted to a specific site
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2 types of dissolution system:
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Encapsulation and matrix
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2 types of diffusion system:
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Reservoir and monolithic
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Osmotic system release constant until:
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Concentration inside falls below saturation
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Overall advantage of osmotic systems:
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Independent of environment (such as pH)
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2 ways GI site specific release can be beneficial:
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Improving bioavailability and treating conditions present at specific site
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GRDF
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Gastroretentive dosage forms
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Esterase and proteolytic activity are lower where?
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In the colon
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Two examples of polymeric nanoparticles:
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PLA and PLGA
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How are lipid nanoparticles different from liposomes?
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No internal aqueous environment
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How do carbon nanotubes recognize cancer cells?
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pH and biological markers
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