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11 Cards in this Set
- Front
- Back
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An intrinsic disease of the articular cartilage, in which biochemical and metabolic alterations result in its breakdown
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Osteoarthritis
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The majority of cases of OA are idiopathic, what type of OA is this?
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Primary OA
Only a small number of cases are secondary to previous fractures, deformities etc. |
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What is normal articular cartilage made of?
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99% extracellular matrix (type II collagen and proteoglycans)
1% chondrocytes |
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What is the name for the chemical in joints that binds water and makes the joint nice and compressively stiff?
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Proteoglycans (collagen provides high tensile stiffness that limits the expansion of proteoglycans)
Remeber: Extracellular matrix is made of proteoglycans and TII collagen) |
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OA: The exposed underlying bone is sclerotic and appears polished - this is known as..?
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Eburnation
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OA pain tends to lessen once the joint has warmed up T/F
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False - pain gets worse with use
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A chronic inflammatory disorder that is characterised by a non-suppurative, proliferative synovitis leading to destruction of the articular cartilage and ankylosis of joints
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Rheumatoid arthritis
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RA affects men more than women T/F
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F - Women are 3-5 times more affected
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RA is thought to be predisposed by genetics T/F
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T
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What antibody is produced in RA? What is it against?
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Rheumatoid factor. It is against the Fc portion of IgG. So, yes, it's an antibody against an antibody. This is a problem because the immune complexes deposit in the joint.
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Rheumatoid factor is present in all patients with RA T/F
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F - only 80% are rheumatoid factor positive
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