Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/15

Click to flip

15 Cards in this Set

  • Front
  • Back
Digoxin
MOA: increases calcium availability

+ inotrope - dromtrop

+ increases contractility
- allows for more filling time
what happens in CHF?
heart losses contractility, blood backs up in heart, less to body,kidney retain more fluid to increase vascular vol in an attempt to increase perfusion. fluid builds up in extremities.
how do vasodilators work to help CHF?
DECREASE PRELOAD AND AFTERLOAD
OPEN THE VESSELS DECREASING BLOOD FLOW RESISTANCE
how do rx work to help CHF?

eg: digoxin
improve contractility of heart and decrease hearts work
how do diuretics work to help CHF?
remove Na and H2O decreasing preload
how do Ace inhibitors work to help CHF?
Vasodilators by decreasing angiotensin II levels.(angiotensin II is a vasoconstrictor).
Thus decreasing afterload.

promotes Na retention

S.E. = Dry NPC, possible worsening of renal function, proteinuris (lots of protein in urine), hyperkalemia (high K) that can be beneficial when used with non K sparing diuretics
Dobutamine

iv use only
Beta 1: + inotrope, increases C.O. and supports BP without peripheral vasoconstriction.This decreases afterload.

increases CO and decreases L. ventr filling pressure.

adv over nor epi and dopamine no increase in o2 demand.
Dopamine
At high doses is an Inotrope and increases C.O.

dose related effect on SVR. Small doses decreases BP by vasodilation . Higher doses increases BP by vasoconstriction.
Nitroprusside: Nipride
Vasodilator, reducing afterload and preload.
Main S.E. is hypotension.

hazard light and heat
Beta Antagonist (beta blocker)

Carvedilol (coreg)
Slows HR, allowing more time for ventricular filling, and reducing Mycardial o2 demand.

Blocking sympathetic outflow will vasodilate as well
Primacor (Milrinone)
phosphodiesterase inhibitor
+ inotrope
vasodilator
increase C.O. & decrease SVR
Inocor (Amrinone)
A phosphodiesterase inhibitor, increase cAMP.
Improves LV function in CHF w/o causing myocardial ischemia.
+ inotrope & vasodilator, increase C.O.
decreases preload and afterload by relaxing vascular smooth muscle.

Used for short term management of CHF in pt who are unresponsive to Dig, diuretics or vasodilators.
Epinephrine
older CHF RX
Alpha & Beta stimulants
Beta 1 increases HR & force.

Alpha increases svr, by causing peripheral vasoconstriction.
Together they increase BP

Beta 2 causes bronchodilation & dilation of blood vessels to deep muscle.

Used to treat asystole or V- fib.
Given during CPR, IV or direct ET instillation. 1:10,000 soln to reduce bleeding Also used to treat anaphylactic shock.
Isoproterenol
older CHF RX
+ chronotrope & inotrope increasing C.O.
but also increase in myocardial O2 consumption.
Its beta 2 Decreases SVR
Used: emergency control of severe bradycardia that does not respond to atropine
svr
systemic vascular resistance