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22 Cards in this Set
- Front
- Back
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Amphotericin B
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Ergosterol pores
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Flucytosine
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DNA interference, decreasing ergosterol synthesis
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Azoles
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CYP450 interference, decreasing ergosterol synthesis
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Echinocandins (e.g. capsofungin)
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Inhibit glucan synthesis
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Griseofulvin
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Inhibits mitotic spindle
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Terbinafine
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Inhibits squalene epoxidase and decreases ergosterol synthesis
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Chloroquine
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Inhibits heme polymerization
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Artemesins
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Increase free radicals
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Doxycycline
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30s ribosomal subunit
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Paromomycin
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Inhibits initiation complex and causes misreading
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Miltefosine
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Inhibits signaling and membrane
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Nifurtimox
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Trypanothione reductase
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Suramin
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Enzymes
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Metronidazole and tinidazole
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Accept electons, bind protein and DNA
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Bactrim
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2-step folic acid
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Pyrimethamine and sulfadiazine
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1-step folic acid
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Albendazole and mebendazole
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Inhibit mictorubule synth, interfering with glucose transport
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Diethylcarbamazine
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Disrupts microfilarial surface membrane
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Ivermectin
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Paralysis and GABA
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Niclosamide
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Uncouples oxidative phosphorylation
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Praziquantel
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Increases membrane permeability to cations, especially Ca++
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Pyrantel Pamoate
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Depolarizing neuromuscular blocker
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