Mnpc Iii Exam 3- Drugs Of Abuse

Front 1

hallucinegens/psychotomimetics- produce what effects (4)

Back 1

produce delirium, true hallucinations (neurons being excited)), loss of contact with reality, death

Front 2

psychotomimetics/hallucinegens- hollister's definition (4)

Back 2

upon a single effective dose:

cause changes in thought, mood and perception with little memory impairment

produce little stupor/narcosis or excessive stimulation (amphetamines)

produce minimal autonomic side fx

are non addicting

Front 3

why study these agents? (4)

Back 3

hallucinegens as as tools for studying psych diseases (LSD for schizo)

basic neurochemical mechanisms in the brain

NT functoin
GPCR research

Front 4

classes of psychotomimetic agents (6)

Back 4

LSD
phenylethylamine
indole alkylamines (serotonergic)
phenylcyclohexyl (PCP)
N-methyl 3 piperidyl benzilate (Anticholinergic)
canniboids

Front 5

Back 5

LSD

Front 6

name the type of activity it has as well

Back 6

indole alkylamine (serotonergic)

Front 7

Back 7

PCP (phenylcyclohexyl)

Front 8

mimics what structure

Back 8

phenylethylamine
(mimics DA/NE structure)

Front 9

classical hallucinogen properties (3)

Back 9

meet hollister definition
bind to 5HT2 receptor
recognized by DOM trained animals (behavioral)

Front 10

dissociative agent properties (3)

Back 10

blocks or reduces signals to cortico/conscious mind

detachment from environment

inhibits sensations from physical senses

Front 11

animal vs human studies for psycho agents (4)

Back 11

human subjects should be best suited to provide most reliable assessment of actoins/potency of psychotomimetic agents- but...

case studies not that well controlled (limited pops, few drug doses, anecdotal)

very few approved clinical studies in humans for psycho agents

therefore we rely heavily on animal studies

Front 12

drug discrimination paradigm (testing method?) properties (3)

Back 12

1) used for a variety of psychoactive agents
2) does not represent a model of psychomimetic activity
3) general applicability and is used to study stimulants, barbs, CNS agents, etc.

Front 13

describe drug discrimination paradigm general concept (2)

Back 13

animals trained to discriminate the stimulus of a training drug (known MoA agent) vs vehicle (saline, DMSO, water)

then animals are taught to associate the effect of training drug with one specific lever, and one lever for vehicle

Front 14

DDP - describe how animals are trained (4)

Back 14

2 levers in training boxes

lever A if saline will give animal food

lever B will give food if animal is injected with LSD

now you can test an unknown substance to see if it produces pharmacologically similar effects to training drug

Front 15

DDP- accuracy rate
dose dependency?

Back 15

trained animals respond 80% of the time or better to the appropriate drug

dose dependent- lower drugs = more mistakes, so can correlate # of mistakes to potency of drug via dose response curve

Front 16

DDP challenge drug

Back 16

drug with unknown MoA- want to see if it gives similar stimulus effect

Front 17

what is stimulus generalization?

Back 17

important note: if similar stimulus effect to training drug is instigated we call it stimulus generalization. this does NOT mean they have the same MoA.

Front 18

non-classical hallucinogens

Back 18

canniboids

PCP

Front 19

3 common species of marijuana

Back 19

cannabis sativa
cannabis indica
cannabis ruderalis

Front 20

3 major presentations of pot- order in level of potency from highest to low

Back 20

hashish- pure resin- most potent
ganja- flowering tops of plants- second most potent
bhang- leaves and stems- least potent

Front 21

major active constituent of canniboid/pot

Back 21

delta 9 THC

Front 22

delta 8 THC

Back 22

less potent version of delta 9 THC

Front 23

major metabolite of THC
activity

Back 23

11 hydroxy delta 9 THC

retains some activity

Front 24

THC absorption (3)

Back 24

most rapid through inhalation
absorbed through gut

absorbed by body tissue then released slowly back into recirculation (hence why it lasts so long in your body)

Front 25

how long dose THC stay in body

Back 25

D2O (deterium) labeled delta 9 THC has been detected even after 2 weeks in body after a single dose

Front 26

THC tolerance and addiction

Back 26

delta 9 THC dose develop but does not lead to physical dependence (addiction- as in you get withdrawals)

Front 27

negative effects of MJ (4)

Back 27

marijuana can impair memory, performance and learning- produces an amotivational sequence

Front 28

CP55940

Back 28

cannabinoid mimic made by pfizer- induces appetite but never marketed

Front 29

win 55,212-2 - category of compound
activity

Back 29

not really cannabinoid. it is an aminoalkylindole that produces similar fx to THC

Front 30

SR14617A - what's it do? (3)

Back 30

inverse agonist at cannbinoid receptor (produces opposite effect)

attenuates TCH effect

used for weight loss (appetite suppressed)- but if you stop taking it you gain all the weight back

Front 31

indole structure

Back 31

know

Front 32

AE of SR14617A (3)

Back 32

depression
suicide
if used in clinically silent MS pt resulted in sx manifestation that resulted from disruption of normal neuroprotective mechanisms

Front 33

MoA of cannibinoids (receptors affected) (2)

Back 33

affects CB1 and 2 receptors

Front 34

CB1 vs CB2

Back 34

CB1 is found in brain
CB2 is found in periphery and believed to have immunomodulation effects

Front 35

endogenous cannibinoid (CB1) ligands (3) and potency relative to THC

Back 35

anandamide- less potent
docosatetraenoylethanolamide- more potent
homo-gamma-linolenylethanolamide (least potent)

Front 36

stability of endogenous CB1 ligands vs THC

Back 36

not as stable? listen again

Front 37

how is delta 9 THC metabolized?
potency

Back 37

OH on C11- more potent

Front 38

most potent THC derivatives (SAR)

Back 38

delta 8 THC with 2 methyl groups on alklyl chain

Front 39

delta 8 THC DMH (dimethyl) metabolism

Back 39

hydroxyl group on C11 to 11 hydroxy delta 8 DMH

Front 40

adding hydroxy group to THC- effect on potency

Back 40

makes it more potent

Front 41

what compound is this
potency?

Back 41

delta 8 thc metabolite

more potent (due to OH)

Front 42

compound? potency?

Back 42

hydroxy dimethyl version of delta 8 THC
MOST potent

Front 43

compound?
potency?

Back 43

more potent
metabolite of delta 9 THC

Front 44

compound/potency

Back 44

delta 9 THC
least potent

Front 45

potency
compound

Back 45

2nd most potent
delta 8 THC DMH

Front 46

non cns related disorders treated with weed (5)

Back 46

alleviate IOP in glaucoma
spasticity in MS
tourette's

immune disorders (CB2 related)

weight loss...maybe

Front 47

CNS related disorders that can be treated with weed (5)

Back 47

neuropathic pain
parkinson's disease
epilepsy
drug abuse
psych disorders