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25 Cards in this Set
- Front
- Back
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Determining which anti-biotics inhibit the 30S subunit vs. the 50S subunit.
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buy AT 30, CCELL at 50
30S: Aminoglycosides (gentamicin, amikacin, streptogramin, tobramycin) [bacteriocidal] Tetracyclines [bacteriostatic] 50S: Chloramphenicol [bacteriostatic] Clindamycin [bacteriostatic] Erythromycin [bacteriostatic] Lincomycin [bacteriostatic] Linezolid [variable] |
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The targets of first generation cephalosporins.
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PEcK
Proteus E. coli Klebsiella |
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The targets of second generation cephalosporins
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HEN PEcKS
H. flu Enterobacter Nesseria Proteus E. coli Klebsiella Serratia |
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Side effects of vancomycin
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Well tolerated in general - does NOT have many problems
Nephrotoxicity Ototoxicity Thrombophlebitis ("red man" syndrome) |
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Drugs to use for pseudomonas
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TCP
Ticarcillin Carbenicillin Piperacillin Also 3rd gen cephs |
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Spectrum of ampicillin/amoxicillin
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Ampicillin/amoxicillin HELPS kill enterococci
H. flu E. coli Listeria Proteus Salmonella enterococci |
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Which has greater bioavailability, amoxicillin or ampicillin?
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amOxicillin has a greater Oral bioavailability.
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List the bacteriostatics
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We're ECSTaTiC about bacteriostatics
Erythromycin Clindamycin Sulfa Tetracyclines Trimethoprim Chloramphenicol |
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List the bacteriocides
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Very Finely Proficient At Cell Murder
Vancomycin Fluoroquinolones Penicillins Aminoglycosides Cephalosporins Metronidazole |
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Which drug has a narrow spectrum for staph?
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Use naf for staph
nafcillin. |
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Properties of aminoglycosides
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"Mean" GNATS cannot kill anerobes
"Mean" = bacteriocidal Gentamicin Neomycin Amikacin Tobramycin Streptomycin Require O2 for uptake, therefore they are not effective against anaerobes NOT Nephrotoxic (esp when used with cephs) Ototoxic (esp when used with diuretics) Teratogen |
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Properties of demeclocycline
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Demeclocycline is an ADH antagonist, it functions as a Diurectic in SIADH
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Tetracyclines are effective against these bugs
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VACUUM THe BedRoom
Vibrio Acne Chlamydia Ureaplasma Urealyticum Mycoplasma Tularemia H. pylori Borrelia Rickettsia |
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General action of clindamycin
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Treats anaerobes above the diaphragm
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Trimethoprim side effects
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TMP = Treats Marrow Poorly
Megloblastic anemia, leukopenia, granulocytopenia (May alleviate with supplemental folinic acid) |
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Side effects of fluoroquinolones
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FluoroquinoLONES hurt attachments to your BONES.
cartilage, tendon damage |
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Targets of metronidazole
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GET GAP on the Metro
Anaerobic infection below the diaphragm Giardia Entamoeba Trichomonas Gardnerella Anaerobes (bacteroides, clostridium) h. Pylori |
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Antimycobacterial drugs
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RIPE for treatment
Rifampin Isoniazid Pyrazinamide Ethambutol |
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Anti-TB drugs
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INH-SPIRE (inspire)
Isoniazid Streptomycin Pyrazinamide INH (Isoniazid) Rifampin Ethambutol |
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Side effects of Isoniazid
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INH Injures Neurons and Hepatocytes
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The 4 R's of rifampin
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the 4 R's of rifampin
RNA polymerase inhibitor Revs up microsomal P450 Red/orange body fluids Rapid resistance if used alone. |
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Function of ampotericin B
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Amphitericin B "tears" holes in the fungal membrane by forming pores.
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M of A of amantadine
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"A man to dine" takes off his coat.
Blocks viral penetration/uncoating (M2 protein) |
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Function and side effect of amantadine
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Amantadine blocks influenzA and rubellA and causes problems with the cerebellA
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Antibiotics to avoid in pregnancy
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SAFE Moms Take Really Good Care
Sulfonamides - kernicterus Aminoglycosides - ototoxicity Fluoroquinolones - cartilage damage Erythromycin - acute cholestatic hepatitis in mom (and clarithromycin - embryotoxic) Metronidazole - mutagenesis Tetracyclines - discolored teeth, inhibition of bone growth Ribavirin - teratogenic Griseofulvin - teratogenic Chloramphenicol - "gray baby syndrome" |
