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12 Cards in this Set
- Front
- Back
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Binds to RBC and causes themm to agglutinate.
Serves as an attachment protein and induces membrane fusion (which facilitates nucleocapsid into cell) |
HA
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2 parts of HA
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1. Outside is attachment region that binds to receptor
2. Fusion region with stalk. Protein must be cleaved during maturation within stalk |
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How is membrane fusion induced?
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acidic environment induces a conformational change which exposes hydrophobic residues of HA and cause the viral envelope to fuse with membrane.
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Treat for influenza
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Amantadine & rimantadine
Relenza & Tamiflu |
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Amantadine & rimantadine
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neutralize pH of endosome so no membrane fusion. Also block channels formed by M2 protins (allow H to enter virion & prevents viral uncoating and translocation of nucleocapsid).
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Relenza & Tamiflu
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Blocks NA activity which is required for release of virus from surface of infected cell so it prevents spread of virus.
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Mutations frequent in influenza caused by fidelity of RNA pol
More common causes epidemic |
Antigenic drift
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When geonomic segments from each virus can randomly assort producing new antigenic strains
causes pandemic |
Antigenic shift
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Avian flu involves what type of antigenic change that can infect humans?
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drift
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Cleaves sialic acid from host glycoproteins
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NA
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Associated with segmented genome
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NP
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Promotes uncoating and viral release
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M2
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