Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
|
How can we distinguish N. Gonorrhoeae from N. Meningitidis?
|
Gonorrhoeae oxidizes glucose while Meningitidis oxidases glucose AND maltose
|
|
|
Major virulence factors: PI, PII, PIII, Lactoferrin & transferrin, LOS (no O antigen)
|
N. Gonorrhoeae
|
|
|
Causes "PID-pus in dere"
Pharyngitis Conjunctivis Disseminated infection Facilitates HIV transmission |
N. gonorrhoeae
|
|
|
What is the primary virulence factor for N. Meningitis?
|
LOS
Capsule Type IV pili |
|
|
Fever, petechial skin rash, thrombocytopenia (clotting), disseminated intravascular coagulation (DIC), endotoxic shock
|
N. Meningitis
|
|
|
Capillaries broken open, purple rash, lack of circulation causing necrosis
|
Meningococcal septicemia
|
|
|
Difference btw N. Gonorrhoeae and N. Meningitis
|
See paper
|
|
|
What are the differences between Vibrion, ecoli, shigella?
|
Think: all holding hands
Shigella has no flagella and it does NOT ferment lactose or produce H2S |
|
|
Is Shigella a strict pathogen
|
Yes
|
|
|
Major virulence factors for shigella
|
Ipa: invasion plasmid antigens protein
IpaB: lyses endosomal membrane to release bacteria to cytoplasm IcsA, IcsB: intracellular spread on actin tails |
|
|
This bacteria's MOA:
1. Triggers own uptake into intestinal eepithelial cells 2. Escapes from phagolysosome 3. Spreads from cell to cell on actin |
Shigella dysenteriae
|
|
|
AB subunit toxin
|
Imagine Shazam shigella w/ his shiga blaster laser, entering intestingal epi cells, and blasting away ato 60S ribosome, causing epi damage
|
|
|
Growth media for shigella
|
Not resistant to bile salts so can use McConkey agar
|
