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9 Cards in this Set
- Front
- Back
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What virulence factors does legionella pneumophila have to enter phagocytes?
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MOMP: enhances phagocytic uptake by binding to C3b to help uptake by phagocytes by binding to CR1 & CR3.
DOT: inhibits oxidative burst ICM: secretes DOT |
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Uptake into macrophages via coiling phagocytosis-->bacteria multiply to very high numbers-->bacteria produces proteases, etc-->lung damage-->recruit more cytokines which futher inc. lung damage
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Legionella pneumophilia
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How is legionella pneumophila transmitted?
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Inhalation (must penetrate to deep lung)
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What are the reseviors for legionella pneumophilia
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Fresh water streams/lakes
Air conditioning cooling towers Water systems |
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Difference between Strep Pneumonia and legionella pneumophila?
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Legionella pneumophila: Any atypical pneunonia
Step NOT necrotizing & localized to lungs |
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disease where there are not symptoms of pneumonia
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Pontiac fever
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Virulence factors for Mycobacterium tuberculosis
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Think: surfing dude Mike (Mycosides). He is waxing (wax D) his surfboard & has his surfboard cord (cord factor) attached to leg.
Cord factor: inhibit PMN |
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What are the stages of M. Tuberculosis?
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1. Primary TB: asymptomatic, development of small granuloma.
2. Progressive TB or miliary TB: if immune response fails to develop 3. Reactivation or secondary TB |
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Treatment of tuberculosis
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cocktail antibiotics
Ones that disrupt mycolic acid synthesis (isoniazid & methanamide), etc. |
