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23 Cards in this Set
- Front
- Back
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what are they type of ovarian cancer
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epithelial
germ cell sex cord stromal metastatic |
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what are the most common types
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dysgerminoma (35-45%)
immature teratoma (20-36%) endodermal sinus tumour (14.5%) everything else after (14%) |
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germ cell tumours
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20-25% of all neoplasms
5% of all malignant tumours |
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what tumour markers are elevated in dysgerminoma
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LDH and Alkalinephosphatase - NOT AFP
bhcg in 3% |
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what is the prognosis for dysgerminoma
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tumour size
unilaterality ... |
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what is the most common chemotherapy
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BEP
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why don't we give radiation?
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want to protect their ovary
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mature teratoma/dermoid
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benign
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what is rokitansky's protuberance?
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solid prominence is location at the jet to normal ovarian tissue
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what is the most impt prognostic factor?
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GRADE
number of immature neural elements |
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what is the most common sex-cord stromal tumours
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Granulosa cell tumour
2 types - adult (95%), 5% juvenile |
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pathology
and tumour markers |
call-exner
coffee-bean nuclei estrogen inhibin B mullerian inhibiting substance |
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what are the components of the RMI II?
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look it up
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what is HE-4
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human epididymis protein 4
used in ROMA - used for early cancer and endometriosis not currently done in canada |
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what is CA125/CEA <25
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sjls
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path
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serous - psammoma bodies
mucinous - intestinal and endocervical type endometrioid (10%) clear cell - hobnail cells Brenner - walthard rests - or walthard nests undifferentiated |
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"STIC" to the ovary
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Serous tubal intra-epithelial carcinoma
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what is the heritability
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15-20% have familial heredity
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what is the number1 risk factor for ovarian cancer
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AGE
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what is the baseline population risk?
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1.5%
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with one family member with ovarian ca
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3-5% risk (non-BRCA)
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HNPCC
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colon
endometrial ovary stomach |
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what is the most important prognostic factor?
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NO residual disease
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