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19 Cards in this Set
- Front
- Back
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Protein that acts as a catalyst and speeds up rxns is the definition of what?
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An enzyme.
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What is actually measured in enzyme determinations?
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Enzyme activity.
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What is the name given to the substance upon which an enzyme acts?
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Substrate.
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Why is serum required for enzyme determinations?
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Anticoagulants interfere with some assays.
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In what disease do the highest elevations of ALP occur?
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Paget's disease; (a bone disease)
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In what clinical condition are the highest levels of CK seen?
(hint: CK-3/MM) |
Muscular dystrophy.
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What condition results in the highest amounts of LD?
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Pernicious anemia.
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Name the 3 isoenzymes of CK and the tissue that has the highest concentration of each.
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CK-1(BB) [B]rain
CK-2(MB) heart CK-3 (MM) skeletal [M]uscle |
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What is the most specific cardiac ENZYME?
What cardiac MARKER is most specific? |
CK-MB
Troponins |
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How are both CK-MB & troponins measured? (Testing method)
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Immunoassays.
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Can a negative myoglobin within 6 hours of chest pain rule out AMI?
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Yes. It is non-specific but sensitive marker for AMI that is elevated within 4 hours of onset of pain & remains elevated for 24hrs.
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What inflammation marker also appears to be associated with risk of coronary heart disease?
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CRP
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What 3 enzymes are included in a liver fx panel?
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ALT, AST, ALP (alkaline phosphatase)
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What is the clinical significance of ACP? (ACID phosphatase)
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Elevated in prostatic cancer & indicates semen presence in rape cases.
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Which stays elevated longer serum or urine amylase?
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Urine.
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5'NT significance in distinguishing btwn bone or liver disease when ALP is elevated.
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Increased in liver but not bone disease.
Increased ALP & 5'NT=liver disease Increased ALP & normal 5'NT=bone disease |
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What tissue other than the pancreas will show elevated amylase levels?
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Salivary gland.
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Do lipase or amylase levels remain elevated longer in acute pancreatitis?
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Lipase.
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CK-MB remains elevated for ___ days in AMI.
Troponin? |
CK-MB 2-3 days.
Troponin 10 days. |
