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34 Cards in this Set

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sensory innervation of the breast

anterior and lateral cutaneous branches of the 4th-6th intercostal nerves (ventral rami of T4-T6)

sympathetic innervation of the breast

reach the blood vessels, glandular tissue, and smooth muscles by way of 2nd -6th intercostal nerves

fetal development of breasts

mammary ridges on either side of the body from the arms to the legs; starting in the 6th week there is the formation of a primary bud which grows secondary buds and then a mammary pit forms and lactiferous ducts are formed

amastia

lack of breasts (if the mammary ridges disappear)

polymastia

many breasts; if the mammary ridge forms an accessory breast at an additional location on the mammary ridges

athelia

one nipple; if one less nipple forms

polythelia

many nipples; if an additional nipple forms along the line of the mammary ridge

unilateral hypoplasia

if one breast is a lot smaller (15% less or more) than the other (may impede function in that breast)

gynecomastia

breasts in a man; associated with obesity; can lead to breast cancer in men; can be due to hormonal imbalances due to testicular cancer, suprarenal cancer, or cirrhosis

the breasts at puberty

ovarian hormones induce growth; the ductile system grows primarily from estrogen and the lobular system grows primarily from progesterone

at the end of puberty the brest is

1/3 mammary gland, 1/3 fat, and 1/3 connective tissue

the breasts during pregnancy

additional growth of breast under influence of pituitary, ovarian/placental hormones; ductile system grows due to prolactin and estrogen; progesterone at this stage inhibits lactation

at the end of pregnancy the breast is

40-50% ductile system

lactation in the breast

estrogen and progesterone levels decrease rapidly; progesterone is no longer inhibiting lactation; with suckling (or thoughts of baby) prolactin levels (milk production) and oxytocin levels (letdown) temporarily spike

menopause on the breast

estrogen and progesterone levels drop, leading to delimitation of the entire ductile system, causing the remnants to resemble connective tissue; testosterone (ovarian) levels increase; endogenous aromatase in the breast can convert testosterone to estrogen in the breast- an uptick in hormone sensitive cancer in the elderly and use of estrogen receptor blockers or aromatase inhibitors with active research ongoing as regarding side effects

symptoms of breast cancer

lumps within tissue (andenocarcinomas), peau d'orange (edema of the skin), dimpled skin/inverted nipple, elevation of breast with exercise (signaling something (cancer) connecting the breast with the pec muscle

risk factors for breast cancer

heredity, age, environmental factors, and age

heredity on breast cancer

BRCA1 and BRCA2 are the most well-known factors; at least a dozen other genes have been identified (many of which can co-occur as gene complexes) (with as yet poorly understood interactions); gene screening is expensive and often uncovered

age on breast cancer

by 30 1 in 2500, by 40 1 in 250, by 70 1 in 25; ultimately 1 out of 8

environmental facts and breast cancer

estrogen mimics, general risks

hormone replacement therapy on breast cancer

estrogen mimics

treatment of breast cancer

ranges from lumpectomy (localized excision followed by drug and radiation therapy to prevent redevelopment of cancer) to simple single or simple double mastectomy followed by drug and radiation therapy to radical single or double mastectomy followed by extremely aggressive drug and radiation therapy (extremely rare)

clinical examination of thorax

inspection- visual, look for abnormalities, asymmetries; palpation- feel for bumps, areas of tenderness; percussion- listen for dullness (lack of tympanic sounds) over lungs; auscultation- listen for breathing sounds and to the heart

classification of ribs

by type- true (1-7), false (8-10), or floating(11-12); by form- typical (3-10) or atypical (1, 2, 11, 12); by clinically- normal or anomalous (extra rib)

a dislocated rib versus a separated rib

dislocated= costal cartilage from sternum; separated= rib from costal cartilage

the danger of an extra cerc=vical rib

can compress rivers of inferior trunk of brachial plexus leading to pain in upper limb (one example of thoracic outlet syndrome)

the danger of an extra lumbar rib

can be mistaken for a fractured rib or lead to mistakes in counting vertebra

muscles of the thorax that aid in protection of the thorax and inspiration

serratus posterior superior, serratus posterior inferior, levatores costarum, intercostals, subcostals, and transversus thoracis

muscles not truly of the thoracic cage but do serve a protective role OR air in forced inspiration

trapezius, lat dorsi, rhomboid major and minor, pectorals major and minor, serratus anterior, subclavius, scalenes

blood supply to the thorax

subclavian artery via supreme intercostal to posterior intercostals 1 and 2; thoracic aorta to posterior intercostals 3-11 and subcostal; internal thoracic artery to anterior intercostals 1-6 and, via musculophrenic, to anterior intercostals 7-9; axillary artery to superior thoracic and lateral thoracic

innervation of thoracic cage

intercostal nerves (ventral rami of T1-T11 spina lnerves); subcostal nerve (ventral rami of T12 spinal nere); typically run inferior to their associated rib- inferior to the associated artery which is, in turn, inferior to the associated vein (VAN)

the intercostal/subcostal nerves

typically provide sensory innervation, along with associated dorsal rami, from a dermatome that rings the body - above and below a line defined by the nerve in question, there is overlap and a need to deaden adjacent intercostal nerves in order to deaden any given intercostal space; provide muscular branches of the thoracic cage; provide, by way of fibers from the sympathetic trunk, sympathetic innervation to the blood levels, glands, and smooth muscles of the thoracic cage

the VAN positioning

initially centered in the intercostal space as they exit the spinal column; soon move to a position in the costal groove along the lower edge of the superior rib (so enter just superior to a rib when doing surgery)

during a mastectomy what do you have to watch out for

the long thoracic nerve (which you want to avoid) and the lateral thoracic artery (which you have no choice but to remove)