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17 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Wee-1 kinase |
Phosphorylates sites on CDK to inhibit. At the level of CDK1 before mitosis. |
"a wee bit too much phosphorylation" |
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CDK activating kinase CAK |
Phosophorylates and activate CDK to bind cyclin |
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Cdc25 phosphatase |
Dephosphorylates CDKs to return them to active. At the level of CDK1 before mitosis. |
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p27 |
Inhibits (physically) binding of CDKs and cyclins at the level of G1/S and S. Helps cells withdraw from cell cycle. |
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p21 |
Inhibits cdk activity in repsonse to DNA damage. At the level of G1/S and S. |
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p16 |
Supresses G1-cdk complex activity. Seen inactivated in cancers. |
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APC/C |
Involved in ubiquitination of S and M cyclins (degredation). Drives cells out of mitosis. |
Involves subunits. |
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cdc 20 |
Activating subunit of APC/C |
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cdh1 |
APC/C activating subunit that prolongs APC/C activity throughout G1. Inhibited by CDK activity. |
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SCF |
Targets CDK inhibitory proteins for degradation (ubiquitination) such as p27. Drives cells into S phase. Needs fbox subunit. |
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G1 CDK Complex |
Cyclin D, CDK 4,6 |
DEAB |
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G1/S CDK Complex |
Cyclin E, CDK 2 |
DEAB |
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S CDK complex |
Cyclin A, CDK 2, 1 |
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M CDK complex |
Cyclin b, CDK 1 |
DEAB |
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Smc1 and smc 3 |
Cohesion molecules that help bring sister chromatids together. |
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smc 2 smc 4 |
Condensins that recoil and condense sister chormatids. Helps chromosomes stay together during anaphase and prevents breakage. |
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ATM |
ATM signals p53 that can signal cell cycle arrest. |
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