Misc Pharm For Comlex

Front 1

P-450 Inducers

Back 1

Queen Barb Steals Phen-phen and Refuses Greasy Carbs CHRONICally

Hint 1

- Quinidine (both induction/inhibition)
- Barbiturates
- St. John's Wart
- Phenytoin
- Rifampin
- Griseofulvin
- Carbamazepine
- CHRONIC alcohol use

Front 2

P- 450 Inhibitors

Back 2

INHIBIT yourself from drinking a KEG because it makes you ACUTEly SICk

Hint 2

- Ketoconazole
- Erythromycin
- Grapefruit juice
- ACUTE alcohol use
- Sulfonamides
- INH
- Cimetidine

Front 3

adrenoreceptors

Back 3

alpha 1 (vascular sm mm, sphincters, dilatory mm in eye)
alpha 2 (decrease symp outflow)
beta 1 (myocytes)
beta 2 (myocytes, uterus, periphery)

Hint 3

G proteins:
q (increased ca2+ intracelluarly, increased PKC)
i (decreased cAMP, PKA)
s (increased cAMP, PKA)
s

Front 4

muscarinic receptors

Back 4

M1 (CNS, enteric system)
M2 (heart)
M3 (exocrine glands, bladder, bronchioles, ciliary mm)

Hint 4

G proteins
q (increase Ca2+ in cell, increased PKC)
i (decrease cAMP, PKC)
q

Front 5

dopamine receptors

Back 5

D1 (vascular sm mm)
D2 (transmitter release in brain)

Hint 5

G proteins
s (increase cAMP, PKA)
i (decreased cAMP, PKA)

Front 6

histamine receptors

Back 6

H1 (resp; involved in pain)
H2 (gastric acid secretion)

Hint 6

G proteins
q (increase Ca2+ in cell, PKC)
s (increase cAMP, PKA)

Front 7

Vasopressin

Back 7

V1 (vascular sm mm)
V2 (kidney)

Hint 7

G proteins
q (increased Ca2+ in cell, PKC)
s (increase cAMP, PKA)

Front 8

Name the 6 major direct-acting cholinomimetic agents

Back 8

1. Acetylcholine (prototype)
2. Bethanechol
3. Carbachol
4. Pilocarpine
5. Methacholine
6. nicotine

Front 9

Name the 6 major indirectly acting cholinomimetic agents

Back 9

1. Isofluorphate
2. Echothiophate
3. Parthion
4. Edrophonium
5. Physotigmine
6. Neostigmine

Front 10

What's the difference between a direct and an indirect cholinergic agonist?

Back 10

Direct = binds/activates the muscarinic/nicotinic receptors

Indirect = inhibits AChE to increase the total amt of ACh in the synapse

Front 11

What are the 2 major families of cholinergic receptors?

Back 11

1. Muscarinic
(M1-M3 in ganglia, sm mm, sec. glands, myocardium, CNS)

2. Nicotinic
(Nn, Nm in autonomic ganglia and NM jxn)

Front 12

What are the organophosphates?
What classic symptoms do they cause?
Name the 3 in use today.

Back 12

1. Indirect cholinergic agonist (bind AChE)
2. DUMBBELSS
3. isofluorate, echothiphate, parathion

Front 13

What are cholinergic antagonists?

Back 13

bind cholinergic receptors (both M and N) without trigger usual downstream response

Front 14

What are the 3 subclasses of cholinergic antagonists?

Back 14

1. Muscarinic Blockers
2. NM blockers
3. Ganglionic Blockers

Front 15

What are the 6 major muscarinic antagonists?

Back 15

1. Atropine (prototype)
2. Scopolamine
3. Homatropine
4. Cyclopentolate
5. Tropicamide
6. Pirenzepine

Front 16

What are some other drugs with antimuscarinc properties?

Back 16

1. benztropine (Parkinson's)
2. antidepressants (chlorpromazine)
3. antihistamines (diphenhydramine)
4. antiasthmatics (ipratropium)

Front 17

What are the toxic effects of atropine?

Back 17

Dry mouth (dry as a bone)
anhydrosis (hot as a hare)
tachycardia/cutaneous vasodilation (red as a beet)
blurred vision (blind as a bat)
hallucinations/delirium (mad as a hatter)

Front 18

What are adrenergic agonists?

Back 18

drugs/catecholamines that activate adrenergic receptors (alpha and beta receptors)

AKA sympathomimetics

Front 19

What are some important alpha-selective direct-acting adrenergic agonists?

Back 19

1.Phenylephrine
2. methoxamine
3. clonidine
4. methyldopa

Front 20

What are some important beta-selective direct-acting adrenergic agonists?

Back 20

1. Dobutamine (unstable CHF, shock)
2. Isoproterenol (Heart block, bradycardia)
3. Albuterol
4. Metaproterenol
5. Terbutaline (prevention of premature labor)

Front 21

Name 2 indirect-acting adrenergic agonists.

Back 21

1. Tyramine
2. amphetamine

Front 22

Name 2 mixed (both direct and indirect) adrenergic agonists.

Back 22

1. ephedrine
2. metaraminol

Front 23

what are adrenergic antagonists?

Back 23

drugs that bind to, but don't activate, the alpha and beta adrenergic receptors

Front 24

What are the (7) alpha adrenergic blockers?

Back 24

1. Prozosin
2. Doxazosin
3. Terazosin (above 3 = HTN, urinary retention in BPH)
4. Phenoxybenzamine (NONREVERSIBLE), used for pheo
5. Tamsulosin (BPH)
6. Yohimbine (erectile dysfunction)
7. Phentolamine (pheo)

Front 25

What are the B1-selective blockers? (4)

Back 25

1. atenolol
2. esmolol
3. acebutolol (partial agonist)
4. metoprolol

Front 26

What are some important B2-selective blockers?

Back 26

1. propranolol
2. timolol
3. nadolol

Front 27

What's the advantage of using a B1 selective blocker?

Back 27

They don't cause the bronchoconstrictive and hypoglycemic effects of nonselective beta blockers

Front 28

what are some beta blockers with alpha blocking capacity?

Back 28

1. labetalol - allows peripheral vasodilation in HTN and atrial fib
2. Carvediolol - for chronic CHF and HTN

Front 29

What is an important B2 selective blocker?

Back 29

butoxamine (no current clinical use)

Front 30

What are indirect adrenergic antagonists?

Back 30

they block release of NE from nerve endings and antagonize effects of the sympathetic nervous system

Front 31

What are the two important indirect adrenergic antagonists?

Back 31

Guanethidine (binds to storage vesicles)

Reserpine (blocks NE transport from cytoplasm into vesicles)

Both used very rarely to treat HTN

Front 32

If you weren't studying for boards, what would you be doing right now?

Back 32

use your imagination....

and remember to smile :)