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23 Cards in this Set
- Front
- Back
- 3rd side (hint)
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SLE
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ANA
dsDNA (more specific) SMITH (most specific) RPR/VDRL |
Antibody-mediated IMMUNE COMPLEX deposition
Iatrogenic: Hydralazine, procainamide, INH, methyldopa, quinidine, chlorpromazine Rx: hydroxychloroquine, steroids, ENOXAPARIN if pregnant |
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SLE (hydralazine-induced)
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ANA
Anti-histone |
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RA
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RF
Anti-CCP** (anticyclic citrinullated peptide) ANA (40%) HLA-DR4** |
Rx:
Mild: NSAIDs, hydroxychloroquine, sulfasalazine Moderate: MTX, INFLIXIMAB (anti-TNF), steroids Severe: combinations of the above |
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Polymyositis
Dermatomyositis |
ANA
Anti-Jo-1 |
High risk of MALIGNANCY and ILD
Rx: HIGH-DOSE steroids, MTX, azathioprine (then taper down) |
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Psoriatic arthritis
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HLA-B27
**no rheumatoid factor!** |
Rx: NSAIDs, sulfasalazine, MTX, anti-TNF
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Scleroderma
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Anti-Scl-70
(anti-TOPOISOMERASE ANA) |
A/w pulmonary fibrosis, ARF
Rx: NIFEDIPINE for Raynaud's (avoid caffeine, nicotine) Rx: MTX, steroids, ACEI (protects renal HTN) |
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CREST
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Anti-CENTROMERE
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Better prognosis variant of Scleroderma
Calcinosis Raynaud's Esophageal dysmotility Scleroderma Telangiectasia |
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MCTD
(mixed connective tissue dmg) |
Anti-RNP (ANA)
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Sjogren's syndrome
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Anti-Ro (Anti-SSA) ANA
Anti-La (Anti-SSB) ANA |
Cell-mediated autoimmunity against exocrine glands
A/w RA, SLE, PRIMARY BILIARY CIRRHOSIS Dry nose, mouth, eyes, vagina PAROTID enlargement, purpura peripheral NEUROPATHY IL-1 hyperactivity in CSF |
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HLA-B27
(seronegative spondyloarthropathies) |
Psoriatic arthritis
Ankylosing spondylitis IBD Reiter's syndrome |
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Polymyalgia rheumatica (PMR)
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**negative RF**
ESR elevation (severe) |
Rx: low-dose steroids, then taper
(high-dose if a/w temporal arteritis) |
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Ankylosing spondylitis
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HLA-B27
**no RF, no ANA** (seronegative) |
Rx: NSAIDs, sulfasalazine, MTX, anti-TNF
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Churg-Strauss
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p-ANCA
Allergic angiitis (medium arteries) ASTHMA NEUROPATHY Eosinophilia Purple RASH |
Steroids
Immunosuppressives |
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Kawasaki
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anti-endothelium
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Aspirin high dose (6 weeks)
IVIG |
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Goodpasture's
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Anti-GBM
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DLCO elevated (alveolar hemorrhage)
Crescentic glomerulonephritis w/ IgG deposition Rx: plasmapheresis, steroids |
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Wegener's
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c-ANCA
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Noncaseating granulomas
Upper/lower-respiratory defects CNS, ophtho defect Arrhythmias Rx: emergent steroids, cyclophosphamide |
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Primary Biliary Cirrhosis
(PBC) |
Anti-MITOCHONDRIA
ANA |
a/w RA, Sjogren's, F>M (more 'autoimmune-like')
Pruritus, arthralgia, XANTHOMA, HYPERPIGMENTATION Rx: UDCA, MTX, transplant |
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Primary Sclerosing Cholangitis
(PSC) |
p-ANCA
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a/w UC, M>F
Presentation, biopsy similar to PBC Rx: UDCA, MTX, stenting |
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Celiac sprue
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Anti-endomesial
Anti-gliadin (these are not present in tropical sprue) |
Steatorrhea, bloating, arthralgia
Rx: remove gluten, give steroids (rice and corn is fine) Rx: tetracycline (for tropical sprue) |
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Crohn's disease
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ASCA
(anti-saccharomyces) |
Cobblestoning, ulcers, stricture
Rx: 5-ASA, steroids, antibiotics |
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Ulcerative colitis
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p-ANCA
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a/w primary sclerosing cholangitis
Dx: pseudopolyps, "lead-pipe" Rx: 5-ASA, steroids, COLECTOMY |
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Pauci-immune glomerulonephritis
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p-ANCA
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RPGN (crescentic)
Rx: steroids, plasmapheresis, transplant |
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p-ANCA diseases
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Pauci-immune RPGN
Ulcerative colitis Primary sclerosing cholangitis Churg-Strauss syndrome |
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