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164 Cards in this Set
- Front
- Back
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Which form of electrosurgery will work in a wet field?
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Electrocautery (no current, works via heat)
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What B cell receptor is involved in Ig isotype switching?
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CD40 (IgM-IgG), defects result in hyperIgM syndrome
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Transient bullous disorder of childhood has a defect in what?
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Collagen 7
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Name some ways in which P acnes causes acne
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Activates complement, activates PMN chemotaxis, activates TLR-2 leading to stimulation of pro-inflamm cytokines
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What meds commonly cause blue-gray pigmentation on sun exposed areas?
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Amiodarone, chlorpromazine and tricyclics
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Involvement in in what protein with cicatricial pemphigoid would raise suspicion for malignancy? And which ones?
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Laminin 5 (=antiepiligrin), gastric and lung
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What population’s bones are most affected by oral prednisone?
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Young males, specifically their vertebrae (trabecular more than cortical)
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What enzyme mediates the rate limiting step in porphyria? In what part of the cell does this happen?
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ALA synthase. Mitochondria
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What is the MOA of cantheridin?
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phosphodiesterase inhibitior.
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What is the difference between podophyllin and podophyllotoxin?
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Podophyllotoxin, AKA podofilox or Condolox, is a anti-mitotic agent that reversibly binds tubulin, arresting cells in metaphase. Podophyllin, has the same MOA, contains kaempero and quercetin which are potent mutagens. Both are derived from the May Apple plant.
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What are histo features of aging skin?
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flattened dermo-epidermal junction, occasional nuclear atypia, decrease in the number of melanocytes and Langerhans cells. Changes that are present in the dermis include atrophy, decrease in fibroblasts, mast cells and blood vessels.
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What tropical dz is associated with white islands on a sea of red?
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Dengue Fever
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UVB acts on what to form pre vitamin D3?
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7-dehydrocholesterol
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What artery provides bld supply for nasolabial transposition flap?
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Angular artery
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Gene involved in familial med fever?
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MEFV
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What is the gene product of MEFV
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Pyrin
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Distal subungual onycholysis associated with paronychia is due to
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Scytalidium dimidiatum
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What is the most common drug in pseudoporphyria?
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NSAIDs
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On what part of the body does merkel cell usually present?
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Head and neck
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What cancer is most commonly associated with erythema gyratum repens?
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Lung
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What systemic dz is associated with clear cell syringomas?
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Diabetes
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What is the association with strep iniae?
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Wound from dorsal fin of fish (strep “FINiae”)
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What rate does cutanea larva migrans move thru skin?
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2cm/day
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What org causes cutanea larva migrans?
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Ancyclostoma braziliense
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What family is BP230 a member of?
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Plakin
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What drugs can cuase PGs>?
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Systemic retinoids, capecitabine and indinavir
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Define ointment, cream, gel ,lotion and foam
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Ointment: water in oil emulsion, cream: oil in water emulsion, gel: semisolid emulsion in alcohol base, lotion: powder in water, foam: liquid or solid in gaseous medium
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Gardasil vaccinates for which HPV?
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6, 11, 16, 18
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Connexins are in what type of cellular communication?
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Gap jxns
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What tumor has dorf balls?
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Kaposi sarcoma
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What is a dimorphic fungus?
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Yeast at warmer temps (37) and mold at colder (25deg)
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TOC gene is what dz?
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Howell Evans
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How can you identify poison sumac?
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Leaves of 7 to 13 with one leaf at tip
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What does PAPA stand for?
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Pyogenic arthritis pyoderma gangrenosum acne
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What is the gene for PAPA?
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PSTPIP1 AKA CD2 binding protein
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What dz has a muttion for NOD2?
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Blau
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What dz has AIRE gene?
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APECED
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What dz has FOXP3 gene?
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IPEX
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What is DOOR syndrome?
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Deafness, congenital onychodystrophy recessive form
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What is COIF syndrome?
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Congenital onychodysplasia of the index finger
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What is scrofuloderma?
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Direct extension of TB infection from lymph nodes, bone, etc into skin
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What chromosome contains acid keratins? Basic?
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17/12
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What type of leukemia are pts with NF1 and JXG at risk for?
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CML
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What is DDx for molluscum like papules in HIV pt?
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Crypto, histo, cocci, and penicillosis
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What toxin is responsible for TSS?
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Enterotoxin B and C (non menstrual) and TSST-1 (menstrual)
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What bacteria causes pitted keratolysis?
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Micrococcus sedenditaris
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In addition to Kaposi sarcoma, HHV-8 causes what?
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Primary effusion lymphoma
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What is the name for a dust mite?
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Dermatophagoides
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What has a pseudodarrier’s sign?
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Smooth muscle hamartoma
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A child with a JXG needs to be referred to whom?
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Ophtho
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What are the X linked and Autosomal dominant genes for dyskeratosis congenital?
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Dyskerin/TERC
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What chemical does sculptra contain?
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Poly L-lactic acid
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What filler is FDA approved for lipoatrophy?
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Sculptra
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What are the 3 layers of inner root sheath of hair cuticle?
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Inner root sheath cuticle, Huxley, Henle
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What is the MC location of perforating GA?
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Dorsum of hands
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What mechanoreceptor senses deep touch and vibration?
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Vater-Pacini
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Where do you find Meissners corpuscles?
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In palms and soles
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Multiple DFs seen in what?
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SLE
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What are the MC electrolyte abns seen with cyclosporine?
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Hyperkalemia, hyperuricemia, hypomag
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Irradiance of UV is measured in what?
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Watts
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What keratins are mutated in white sponge nevus?
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4/13/2011
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Mutation in keratins 1/10 cause what?
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Epidermolytic hyperkeratosis and Unna Thost
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What dz has a mutation in fumarate hydratase?
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Familial cutaneous leimyomas
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What dz has a mutation in adenosine deaminase?
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SCID
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What dz has a mutation in endoglin?
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Osler-Weber_rendu (“Renodglein”)
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Red hair people have a mutation in what?
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MC1R (Most Common 1 for Redheads)
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What is a pulmonary side effect in people with TS?
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Pulm lymphangioleiomyoma
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During what month of gestation do melanocytes begin to develop?
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3rd month
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What dz has Lester iris?
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Nail-patella
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What dz has choroid malformations?
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Sturge weber
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Use of methimazole in preg ladies can cause what cutaneous fetal abn?
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Aplasia cutis
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What non cut side effects are associated with yellow nail syndrome?
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Pleural effusions, LE edema, bronchiectasis
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Foamy macrophages with kelbsiella pneumonia are called what?
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Mikulicz cells
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Virchow’s cells are found in what dz?
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Hansens
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Hansemann cells are found in what?
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Malakoplakia
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Collagen VII is a what and located where?
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Anchoring fibril/sublamina densa
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UVAII extends from what to what?
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320-340
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What LFT is zinc dependent?
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Alk phos
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What is the time course of the rash of solar urticarial?
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Wheals begin at 15-30 min and last 1 hr
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Calabar swellings involved in what dz?
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Loiasis (swellings around joints)(
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Latex allergy can cross react with what fruits?
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Kiwi, avocado, bananachestnut
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Where does one catch drcunculiasis from?
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Drinking water infested with copepods
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What abs in DM give increased risk of malignancy?
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155/140
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What abs in DM give increased risk of cardiac involvement/fulminant DM?
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SRP
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What antibiotic commonly increases levels of digoxin?
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Erythromycin
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What is the most common skin condition associated with monilethrix?
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KP
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What dz has a mutation in GJB2?
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Vohwinkel
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Probiotics may be helpful in what skin condition?
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Atopic dermatitis
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What syndromes can present with wooly/curly hair?
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Noonan, Naxos, Carvajal, Costello and trichodentosseous
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What syndromes present with pili torti?
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Menkes and Bjornstad
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What laser has greatest penetration into the skin?
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Nd YAG 1064
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CK20 is useful in the diagnosis of what?
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Merkel cell carcinoma
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What is the MC first sign of HHT?
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Epistaxis
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Apocrine chromhidrosis results from what in apocrine sweat?
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Lipofuschin
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What syndromes have stippled epiphyses?
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CHILD, chondrodysplasia punctata
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Which HPV causes ridged warts?
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60
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Which HPV causes anogenital condyloma and Bucke and Lowenstein?
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6/11/2011
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Which HPV causes anogenital dysplasia?
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18
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What is the ratio of sodium bicarbonate to 1% lido 1n a buffered lido sol’n?
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1:10:00
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Sensory innervation of glabella and mid forehead is provided by which nerve?
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Supratrochlear
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What is the Hoeppli-Splendore rxn?
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Histo:eosinophilic material of fibrin and abs, caused by actinomycosis, staph aureus, proteus and e coli
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What type of hypersensitivity rxn is allergic contact derm?
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Delayed
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What cytokines promote switching from IgM to IgE?
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IL4 and 13
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Of all the candida lesions, which is most likely to cause disseminated dz with cut lesions?
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c. tropicalis
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What drugs can cause sweets?
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G-CSF, ATRA, hydralazine, carbamazepine, OCPs, Spetra, minocin
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What drugs worsen psoriasis?
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Beta blockers, antimalarials, interferon, lithium
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What gene is mutated in MENII?
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Ret
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What are Odland bodies?
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Lamellar granules. Laminated bodies containing ceramide, secretory granules, lysosome-like
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What HLA is associated with DH?
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HLA-DQ
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What drugs can cause cicatricial pemphigoid?
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Clonidine, sulfa drugs and thiol drugs
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Pretesting for allergy to collagen is reqd for what filler?
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Artecoll (bovine collagen) (a for allergy)
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What is the antigen defect in Sneddon-Wilkinson?
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Desmocolin 1
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What specific amino acids are in elastic fibers?
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Desmosine and isodesmosine
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Name members of the plaking family
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BPAg1, desmoplakin, envoplakin, periplakin
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What drug used to tx RA can cause yellow nails?
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D-penicillamine
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What chromosome is MHC on?
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6
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Medlar bodies are diagnostic of infxn with what organism?
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Chromomycosis (copper pennies)
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Which HPV is associated with periungual SCC?
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16
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MC location for nevus anemicus?
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Upper chest
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What is the name for a mass of hyphae?
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Mycelium
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What transmits leishmania donovani?
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Sand fly (phlebotomus)
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Pemphigus is associated wit what HLA?
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HLA-DRw6 or DR4
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Where are steroid receptors located?
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On the nucleus
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What is the antigen found in the variant of cicatricial pemphigoid that is associated with internal malignancies?
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Epiligrin
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Fecal isocoproporphyrin is seen in what porphyria?
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PCT
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What filler can be seen on xrays?
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Radiesse
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What dz has a mutation in laminin 5?
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JEB, Herlitz type
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What dz has a mutation in transglutaminase I?
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Lamellar ichthyosis and nonbullous CIE
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What virus is most associated with oral hairy leukoplakia?
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EBV
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What is the most common orgaism causing eumycotitc mycetoma in the US?
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Scedosporium apiospermum
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What are karuase end bulbs?
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Mucocut receptors on penis, clitoris, labia minora and vermillion border
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What is a chloroma?
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Aka granulocytic sarcoma, green colored occur in leukemia pts
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What keratins would be preferentially expressed in kcytes of a psoriasis plaque?
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6, 16 (marker for hyperproliferative kcytes)
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What are the main features of trichorhinophalangeal syndrome?
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Shortened phalanges, sparse hair and bulbous nose
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UVB converts 7-dehydrocholesterol to what?
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Previtamin D3
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What is an immunohist marker for merkel cells in the skin?
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Keratin 20
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What is the most common cause of photo toxicity?
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Psoralens
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What does finasteride inhibit?
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Type II 5 alpha reductase
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What is the triad of sjogren Larsson?
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Icthyosis, di or tetraplegia, mental retardation
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What are the 3 types of scleredema?
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1
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What direction do hair follicles develop?
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Cephalad to caudal
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b/l retinal hemangiobastomas, capillary malformation on neck, what dz/gene?
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VHL/VHL
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What dz has a mutation in endoglin?
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Osler weber rendu
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What ist he gene in Mafucci?
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PTH/PTHrP
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What is mutated in Nonne-Milroy?
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VEGF
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What deficiency does a pt with a defiency in holocarboxylase synthetase at risk for?
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Biotin
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Oxytalan and elaunin run perpendicular? Parallel to DEJ?
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Oxytalan perp, elaunin parallel
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What medium do u need to fix gout crystals?
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Ethanol
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What organism causes pellosis?
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Bartonella hensalae
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What is denileukin diftitox?
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Diphtheria fusion protein targets IL-2 receptor, used for CTCL
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What is theMC cause of eumycotic mycetoma in US?
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Pseudallescheria boydii
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Bcl-1 is a marker for what type of lymphoma?
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Mantle cell
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What retinoid is not excreted in the urine?
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bexarotene
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What lasers may cause milia as a postprocedure complication?
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Erbium and CO2
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What does bodiam stain?
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Nerves
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What does methyl green pyronin stain?
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RNA/DNA
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Which type of collagen is first to deposit in a wound?
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III
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How do u treat Leish?
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Pentavalent antimony
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What immunosuppressant may give a protective effect against SCC in organ transplant pts?
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Rapamycin
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What is the MC location of DFSP?
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Trunk
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What is the half life of isotretinoin?
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20 hrs
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Which UV causes immediate pigment?
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UVA
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What type of virus is measles?
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Paramyxovirus (RNA)
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What is the other name for vit B2 and what sxs do you get with a deficiency?
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Riboflavin/Angular cheilitis, atrophic glossitis, photophobia, blepharitis, genital dermatitis, seborrheic dermatitis around the nose
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