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137 Cards in this Set
- Front
- Back
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What is the MOA of Nystatin?
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Irreversibly binds to membrane sterols and cause a permeability shift
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What is the MOA of ciclopirox?
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Interferes with cell respiration
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In a pt with BP, when a salt split skin DIF is performed, where would you expect to see deposits?
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Epidermal side
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What about in epidermolysis bullosa acquisita or anti-epiligrin pemphigoid?
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Dermal deposits
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What organism causes pinta?
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Treponema carateum
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1% lidocaine is how many g/ml?
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1g/100ml
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How long does lidocaine without epi last/
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30-60 min
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Max dose lido without epi
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4.5mg/kg
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Max dose lido with epi
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7mg/kg
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When people have a lidocaine allergy, what is it that they are allergic to?
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Paraben preservatives
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PDGF gene has been shown to be translocated into the collagen I gene in what tumor?
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Dermatofibrosarcoma protuberans
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What skin finding do you see in Pellagra?
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Triad of diarrhea, dermatitis and dementia. Dermatitis is a burning erythema in sun exp areas, may have bullae and erosions followed by a dry brittle, scaling and hyperpig plaques
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What is the deficiency seen in Pellagra?
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Niacin and tryptophan
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What is the TOC for Loiasis?
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DEC Diethylcarbamazine
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What organism can you get from swimming with dolphins
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Lobomycosis, shows up on ears, face arms, looks like keloids
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What comprises Jacquets diaper dermatitis is caused by what?
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Multifactorial: yeast irritants and moisture
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cryptococcus
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Blasto – skin
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What are the 3 types of minocin hyperpigmentation? And what histo stains?
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1-blue black in areas of prior injury, stains iron and melanin 2-blue-gray on lower legs and forearm, stains iron and melanin 3-muddy brown sun exp areas-increased melanin at basal layer
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What is Brooke-Spigler syndrome?
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Multiple cylindromas and trichoepitheliomas
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TH1 response-what cytokines?
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IL2, IFN gamma, TNF beta
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TH2 response what cytokines?
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IL4, 5,6, 10, 13
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Which is antibody mediated and which is cell mediated?
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TH1-cell mediated, TH2-ab mediated
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What antibodies are implicated in relapsing polychondritis?
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Abs to anti type II collagen
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How often do pts die of RP? And due to what?
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1/3, 2/2 airway collapse/CV complications and infections from steroids
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Where do you biopsy a pt you suspect has rabies?
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Neck (virus migrates spinal cord to peripheral nerves to skin, intestine and salivary gland)
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What HLA type is associated with HSV erythema multiforme?
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HLAB15
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Hidraenitis suppuritiva, dissecting cellulitis of the scalp and what make up the follicular occlusion triad?
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Acne conglobate
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What is the most common eye finding in cutis marmorata telangiectasia congenital?
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Glaucoma
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What other genoderms have glaucoma?
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NF1 and sturge weber
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What disease has DIF staining of intercellular spaces and BMZ?
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Paraneoplastic pemphigus and drug induced pemphigus
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Where does anti-epiligrin pemphigoid stain?
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BMZ (dermal staingin on slat split skin)
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Where does pemphigus vegetans stain?
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Intercellular spaces and not BMZ
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What else stains there?
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Pemphigus follaceous and IgA pemphigus
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What kind of hormone cause centripetal obesity?
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Cortisol
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What diseases can cause Blueberry muffin baby?
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TORCH, severe anemia (such as hemolytic dz of the newborn), neoplastic dz such as rhabdomyosarc
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Name some non transgradiens PPK
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Naxos (Plakoglobin), Howel-Evans (TOC), non-epidermolytic PPK /Unna Thost(K1), Epidermolytic PPK/Vorner (K9)
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What disease involves protein SLURP-1?
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Mal de Meleda
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What is the gene that is mutated?
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ARSB
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What drugs commonly are responsible for lichenoid drugeruption?
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Antimalarials, beta blockers, captopril, gold, penicillamine, HCTZ, NSAIDs
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Does mucicarmine stain crypto?
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No
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What big city is an endemic area for blastomyces?
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Chicago
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What are symptoms of Vogt-Koyanagi-Haradi syndrome?
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b/l granulomatous uveitis, vitiligo, deafness, poliosis and alopecia
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What tumors are seen in Brooke-Spiegler?
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Cylindromas, trichoepitheliomas, spiradenomas
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What are some findings of Alagille syndrome?
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Arteriohepatic dysplasia amd nevus comedonicus
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What symtpoms are seen in Nicolau-Balus syndrome?
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Multiple eruptive syringomas, milia and atrophoderma vermiculata
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What symptoms are seen in Schopf’s syndrome?
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Multiple apocrine hidrocystomas, PPK, teeth abns and onychodystrophy
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What symptoms are seen in Lhermitte-Duclos?
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Prolierfation in the cerebellum (dysplastic gangliocytoma) with macrocephaly
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What are floret giant cells?
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Pleomorphic enlarged fat cells with nuclei arranged in circumferential pattern. Associated with pleomorphic lipoma
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Structures that freely slide along the hair shaft. Whats the diagnosis?
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Hair casts, nml in kids btwn 2-8yrs, distinguish from nits assd with lice which are adherent
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Whats the doctor word for split ends?
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Trichoptilosis
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What is the significance of furocoumarins?
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May cause a phytophotodermatitis that is a phototoxic rxn
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What is the time course for phototoxic rxns?
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Mins to hrs after exp
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What protein mutation has been linked to epidermolysis bullosa with muscular dystrophy?
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Plectin
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Whats the mnemonic assd with nai patella?
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Triangle NAILS: Nephritis, Absent patella, Iliac horns, LMX1B and Sweaty
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What is Schnitzler’s Syndrome?
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Urticarial vasculitis with monoclonal IgM, fever, LAD, HSM, bone pain and sensorimotor neuropathy. Schnitzler is friends with Waldenstrom
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Which antifungal can cause gynecomastia and impotence?
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Ketoconazole
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Which complements are low in lupus erythematosus-associated complement def?
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C2 and 4
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What dermatophyts is responsible for bullous tinea pedis?
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T. mentagrophytes
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What is a chloroma?
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A greenish tumor, associated with leukemia, green due to myeloperoxidase
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What org causes LGV?
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Chlamydia trachomitis
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What causes black dot ringworm?
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T. violaceum
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What orgs can cause tinea capitis?
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Ringo Gave Yoko Two Squeaky Violons: T: rubrum, gourvilli, yaounde, tonsurans, schoeleinii, soudanense, violaceum
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What is Schimmelpenning syndrome?
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Nevus sebaceous and szs, mental retardation, colobomas, skeletal, cardiac and GU abns
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What is the most common cause of tinea capitis?
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T tonsurans
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What is the most molecular defect in chronic granulomatous dz?
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Mutation in gene coding b subunit of cytochrome b
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Carriers of chronic granulomatous dz have an increased prevalence of what autoimmune dz?
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DLE
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In what disease is L-Myc Elevated?
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Merkel Cell Ca
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GLI-1?
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BCC, it is a tf in Sonic hedgehog pathway
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CDKN2A
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Familial forms of melanoma that are assd with pancreatic ca
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What diseases involve PTEN?
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Cowden, Proteus and Bannayan-Riley-Ruvalcaba
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Ingestion of lots of what cuases eosinophilia-myalgia syndrome?
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Tryptophan
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What dose IL-5 do to eos?
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Upregulates them
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What allergen is detected using the dimethylyglyoxime test?
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Nickel
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What type of malignancy are men with X linked ichthyosis at higher risk for?
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Testicular ca
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Risk of fetal death with intrauterine parvovirus infection may occur during which trimester?
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All of them (2nd is greatest risk)
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How can parvovirus affect a fetus?
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Fetal hydrops, no congenital anomalies
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What genoderms are associated with elastosis perforans serpiginosa?
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PROMEDA: PXE, Rothmund-Thomson, Osteogenesis imperfect, Marfan, Ehlers-Danlos, Down, acrogeria
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What is the primary autoag in pemphigoid gestationis?
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BPAG2
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What test is used to diagnose chronic granulomatous dz?
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Nitroblue tetrazolium reduction assay
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What enzyme is defective in familial multiple cutaneous leiomyomas?
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Fumarate hydrotase
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What enzyme is defective in Niemann-Pick?
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Sphingomyelinase
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What enzyme is defective in Gaucher dz?
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Glucocerebrosidase
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What HLA type is most associated with psoriasis?
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HLA-Cw6
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What is Riga-Fede dz?
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Benign ulcerative granulomatous dz in rxn to chronic repetitive trauma of oral mucosa by the teeth, appearing as firm verrucous plaques. May be associated with a neuro disorder
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What kind of amyloid is deposited into the skin in lichen amyloidosis?
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Keratin derived amyloid
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What is the peak wavelength of PUVA bulbs?
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352 nm
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Mercury vapor lamps?
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254nm
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Narrow band UVB?
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311-12
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Histologic description of DFSP
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Monomorphic spindle cells arranged in a storiform pattern or cartwheel pattern
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What is a Michaelis-Gutman body?
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Inclusion body in a macrophage seen in malakoplakia, concentrically laminated spherical inclusion containing calcium
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Name two other calcium containing inclusion bodies
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Schaumann bodies, psammoma bodies
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What disease has Negri bodies?
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Rabies
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What dz has Lipschutz bodies?
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Herpes (intranuclear inclusion) AKA Cowdry A body
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What dz has the Guarnieri body?
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Smallpox
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What are the perivascular deposits seen in HSP?
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IgA
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What tumor suppressor genes are commonly mutated in SCC?
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P53 and p16
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What HLA is associated with Behcet’s disease?
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HLA-B51
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How should chronic paronychia be treated (general classes)?
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Antifungal and sterois. Likely is a contact rxn and superinfxn with candida
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Where is the cleft in cicatricial pemphigoid?
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At the BMZ-antigens are BPAg2, laminin 5 and alpha-6-beta4 integrin. DIF shows IgG and complement in BMZ
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What is the recommended period for contraception after cessation of acitrtin?
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3 years
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Cutaneous warts in renal transplant recipients whow increased expression of what keratin?
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K13
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What about Botox makes it painful?
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The preservative-free saline. Botx with preservative is less painful
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What is the difference btwn acqd and inherited C1 esterase inhibitor deficiency?
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Acquired C1 esterase inhibitor deficiency occurs in the setting of lymphoproliferative disease, MGUS, or rheumatologic disease and results in a decreased serum C1q level. Inherited shows an autosomal dominant inheritance, and earlier presentation, and a normal level of serum C1q. In the inherited disease, the C1 esterase inhibitor may display normal levels but be functionally impaired.
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What therapeutic agent can cause neutrophilic eccrine hidradenitis?
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Cytarabine (pt wth AML)
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What is the etiology of lupus vulgaris?
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Spread of TB from a distant site, apple jelly appearance
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What is the only cutaneous manifestation of vit D def?
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Alopecia
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What is the only cutaneous manifestation of B1 def?
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Berberi (thiamine), edema
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Sticky skin is caused by what drug combo?
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Doxorubicin and ketoconazole (ketone sticking to a Doxon) and etretinate and tretinoin
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Name the dx criteria for Sweets
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Need 2 major and 2 minor. Major: juicy painful plaques/bullae, PMN infiltrate in dermis. Minor: presence of assd condition, fever/malaise, abn lab values (ESR, CRP), good result to prednisone
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Wrinkle resistant clothing is treated with what allergen?
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Formaldehyde
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Chewing gum contains what allergen?
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Rosin (colophony)
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Permethrin allergy can cross react with allergy to what flower?
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Chrysanthemums
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What type of flies are horseflies and deer flies?
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Tabanid
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What are Moll glands?
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Modified apocrine glands on the eyelid
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What do you call sebaceous glands on the eyelid?
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Wolf or Meibomian
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How much does desmoglein 1 weigh?
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160kDa
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How much does desmoglein 3 weigh?
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130kDa
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What MHC do keratinocytes express?
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MHC I (can be induced to express II in inflammatory conditions)
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What is the most common site for lesions in nephrogenic fibrosis dermopathy?
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Lower ext
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What is the initial lab w/u for PCOS?
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Free and total testosterone, LH, FSH, DHEA-S
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What organism causes cutaneous larva migrans?
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Ancylostoma caninum and brazilense
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What organism is assd with pools?
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Mycobacterium marinum
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What is the treatment for a skin infection with it?
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Minocin
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What is rhinoscleroma?
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Chronic granulomatous infxn of the nose and UR tract by klebsiella pneumonae rhinoscleroma
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How long is the lifecycle of scabies?
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1 month
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What topical antibiotic has the potential to cause neutropenia?
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Silver sulfadiazine
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In paraneoplastic pemphigus, what is deposited at the DEJ on DIF
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C3
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What medication is assd with acqd brachial dyschromatosis?
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ACEI
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What does the rash look like?
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Asympt gray brown patches with geographic borders, interspersed with hypopig macules on dorsum of forearms
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What chemical is assd with shoe sermatitis?
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Mercaptobenzothiazole (in rubber)
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What is the tx for Norwegian scabies?
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Ivermectin
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This medication is also FDA approved for tx of what?
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Strongyloides and onchocerciasis
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Time anesthetics last
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Procaine: 15-60 min, Diphenhydramine: 30 min, Lidocaine without epi: 30-60 min, Lidocaine with epi: 120-360 min, Lidocaine with epi: 120-360 min, Bupivicaine without epi: 120-240 min, Bupivicaine with epi: 180-420
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What is pityriasis rotunda?
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Discrete circular brown scaly patches on trunk and ext, assd with systemic dzs in blacks
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What cancer is linked to pityriasis rotunda?
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Hepatocellular ca
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What do you call a discrete patch of atrophic alopecia in a child?
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Aplasia cutis congenital
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What organelles do Mulberry cells have increased number?
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Mitochondria
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