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7 Cards in this Set
- Front
- Back
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What are the major principles of immunity?
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- Highly specific recognition of foreign antigens with potent
mechanisms for pathogen elimination - A vast universe of distinct antigenic specificities. - The capacity to display immunological memory. - Tolerance to self-antigens |
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Why get adaptive immunity?
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- specificity
- memory - fine-tuning (speed, magnitude, affinity and efficiency) |
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How does T-cell homing occur?
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step-wise:
- rolling (with help of L-selectin) - activation - adhesion (with help of LFA-1) - diapedesis (into lymph node cortex) |
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What does L selectin (CD62L) bind to?
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- sulfated sialyl Lewis x (SLeX)
- CD34 and GlyCAM on LN HEV - MAdCAM-1 on endothelium in mucosa |
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What happens to L-selectin once T cell encounters Ag?
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expression of L-selectin is lost or highly downregulated
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What adhesion molecules are involved in T cell interactions?
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Leukocyte adhesion molecules:
- selectins (L-selectin) - addressins (CD34, GlyCAM-1) - integrins (LFA family members - integrins alpha/beta subunits) - Ig superfamily (ICAM) |
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What are cell adhesion molecules important for in immunity?
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Stabilizing T-APC interactions
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