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9 Cards in this Set

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  • Back
Exotoxiny
(definice)
toxicke bakterialni protein
produkovane G+bakteriemi
antigenni a toxicita
Exotoxiny
(deleni)
Neurotoxiny (botulunim, tetanospazmin)
Enterotoxiny (choleragen, termolablni a termostabilni toxin E.Coli, stafylokokove enterotoxiny)
Proteolyticke toxiny (proteinasy)
Cytotoxiny (cytolysiny)
Hemolysin
Hydrolyticke enzymy (kolagenaza,hyaluronidas,streptokinasa)
Superantigeny(TSST-1, exfoliativni toxin, M-protein)
Komplexni toxin (antraxovy toxin Bacillus antracis)
Cytolyticke toxiny
extrace. bilkoviny pusobici primo na membrany eukaryotnich bb.
Zpusob poskozeni:
- Enzymovou hydrolyzou membranovych fosfolipidu fosfolipasami C a D
- Tvorbou poru po vazbe na cholesteolu
- Povrchove aktivnimi hemolysiny- gama lysin St.aureus
- Inserci do lipidove bb. tvorici pory

Uvolnuji jine mediatory> zanet
Intracelularne pusobici bakterialni toxiny
3 faze:
- vazba toxin na spec. receptory na membrabe bb.
- translokace toxinu pres membranou
- interakce se substratem v cytoplazme

-fragment A(enzymove), sam o sobe netoxicky,pronika do cytosolu
-fragment B(receptove),zustava vne
cela molekula je enzymove inaktivni

1.diftericky toxin
2.choleragen, termolabilni toxin E.coli, toxin Bordtella pertussis
3.Botulotoxin,tetanospazmin (zvlatne)
Neurotoxiny
toxicke latky produkovane G+ bakteriemi, pusobi na nervovy system.
-botulotoxin a tetanospazmin
(Cl.botulinum, Cl.tetani)
Botulotoxin
zinku-zavisle endopetidazy
stepi synaptobrevin>uvolnuji neurotransmitery
Lehky retezec (aktivni)
Tezky retezec (vazebna)

Blok uvolnovani acetylcholinu->irreverzibilni ochabnuti sval->smrt v dusledku paralyzy dych. svalu
Tetanospazmin
Cl. tetani (anaeroby)
vychytavan nervvymi zakoncenimi->sede hmoty prednich rohu misnich-> do bb.
blokuje uvolnovani neurotransmiteru->krecim pricne pruhovane svaloviny

lakalni neurotoxiny: enterotoxin St.aureus->zrychleni peristalticky streva->prujmy; iritace veg. nerveho syst.->zvraceni
Enterotoxiny
G+ iG=
enzymatickou a termolabilni
nizkou toxicitou
ruzne GIT-onemocneni->prujmy, zvracni, dehydratace,

Choleragen
Shiga-toxin
enterotoxin E.coli->nepusobuji zanetlive zmeny sliznice->prujem
Enterotoxiny Clostridia.
enterotoxin St. aureus
Superantideny
nevyzaduji pro svoji innterakci s imunitni systemem zpracoani antigen prezentujicimi bunkami
schopnost vazat na T receptory, MHC II makrfagu
Enterotoxin,TSST-1 St.aureus,
Superantigen mykoplazmat, pseudomanad,
Enterotoxin Cl. perfringens

Protilatkova odpoved je potlacvana superantigenem- podani predchazi aplikace antigenu
stimulovana pri podani nasladne po antigenu

vznik autoimunitni noemoc
zvusyji citlivost k ucinku endotoxinu G-