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9 Cards in this Set
- Front
- Back
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Exotoxiny
(definice) |
toxicke bakterialni protein
produkovane G+bakteriemi antigenni a toxicita |
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Exotoxiny
(deleni) |
Neurotoxiny (botulunim, tetanospazmin)
Enterotoxiny (choleragen, termolablni a termostabilni toxin E.Coli, stafylokokove enterotoxiny) Proteolyticke toxiny (proteinasy) Cytotoxiny (cytolysiny) Hemolysin Hydrolyticke enzymy (kolagenaza,hyaluronidas,streptokinasa) Superantigeny(TSST-1, exfoliativni toxin, M-protein) Komplexni toxin (antraxovy toxin Bacillus antracis) |
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Cytolyticke toxiny
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extrace. bilkoviny pusobici primo na membrany eukaryotnich bb.
Zpusob poskozeni: - Enzymovou hydrolyzou membranovych fosfolipidu fosfolipasami C a D - Tvorbou poru po vazbe na cholesteolu - Povrchove aktivnimi hemolysiny- gama lysin St.aureus - Inserci do lipidove bb. tvorici pory Uvolnuji jine mediatory> zanet |
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Intracelularne pusobici bakterialni toxiny
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3 faze:
- vazba toxin na spec. receptory na membrabe bb. - translokace toxinu pres membranou - interakce se substratem v cytoplazme -fragment A(enzymove), sam o sobe netoxicky,pronika do cytosolu -fragment B(receptove),zustava vne cela molekula je enzymove inaktivni 1.diftericky toxin 2.choleragen, termolabilni toxin E.coli, toxin Bordtella pertussis 3.Botulotoxin,tetanospazmin (zvlatne) |
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Neurotoxiny
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toxicke latky produkovane G+ bakteriemi, pusobi na nervovy system.
-botulotoxin a tetanospazmin (Cl.botulinum, Cl.tetani) |
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Botulotoxin
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zinku-zavisle endopetidazy
stepi synaptobrevin>uvolnuji neurotransmitery Lehky retezec (aktivni) Tezky retezec (vazebna) Blok uvolnovani acetylcholinu->irreverzibilni ochabnuti sval->smrt v dusledku paralyzy dych. svalu |
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Tetanospazmin
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Cl. tetani (anaeroby)
vychytavan nervvymi zakoncenimi->sede hmoty prednich rohu misnich-> do bb. blokuje uvolnovani neurotransmiteru->krecim pricne pruhovane svaloviny lakalni neurotoxiny: enterotoxin St.aureus->zrychleni peristalticky streva->prujmy; iritace veg. nerveho syst.->zvraceni |
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Enterotoxiny
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G+ iG=
enzymatickou a termolabilni nizkou toxicitou ruzne GIT-onemocneni->prujmy, zvracni, dehydratace, Choleragen Shiga-toxin enterotoxin E.coli->nepusobuji zanetlive zmeny sliznice->prujem Enterotoxiny Clostridia. enterotoxin St. aureus |
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Superantideny
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nevyzaduji pro svoji innterakci s imunitni systemem zpracoani antigen prezentujicimi bunkami
schopnost vazat na T receptory, MHC II makrfagu Enterotoxin,TSST-1 St.aureus, Superantigen mykoplazmat, pseudomanad, Enterotoxin Cl. perfringens Protilatkova odpoved je potlacvana superantigenem- podani predchazi aplikace antigenu stimulovana pri podani nasladne po antigenu vznik autoimunitni noemoc zvusyji citlivost k ucinku endotoxinu G- |
