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9 Cards in this Set
- Front
- Back
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What is first line treatment for migraines?
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excedrin migraine (acetaminophen+aspirin+caffeine)
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Why is caffeine useful in treating migraines?
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vasodilator in periphery but cerebral vasoconstrictor
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What is the mechanism of action for ergot alkaloids?
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nonspecific serotonin agonists
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Prolonged use of ergotamine could result in this.
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rebound headaches
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Why can ergot alkaloids cause hypertension?
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SNS vasoconstrictor which constricts ALL vessels
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Adverse reactions to ergot alkaloids
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MI, drug dependance
HTN, portal HTN, hypothermia |
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Contraindications to ergot alkaloids
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CV disease
obesity hepatic and biliary disease Pregnancy X Renal disease |
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Which serotonin-1 agonist (triptan) is biotransformed by the CYP450 system rather than by MAO?
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naratriptan
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Contraindications to serotonin-1 agonists
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CV disease (CAD and Prinzmetal angina)
HTN MAO inhibitor use within 2 weeks Ergot use within 24 hours orther triptans within 24 hours |
