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10 Cards in this Set
- Front
- Back
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Sumatriptan
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Serotonin analog that activates 5-HT receptors in brain to constrict vessles and reduce production of inflammatory substances
Reduces headaches, nausea/vomiting, pain |
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Side Effects of Sumatriptan
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May effect coronary circulation
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Second generation triptans
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high BBB penetrance and more effective
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First dosing of sumatriptan
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Give in physicians office to monitor for Printzmetal's angina
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Ergotamine and dihydroergotamine
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Older migraine drugs that activate serotonin, DA and alpha adrenergic receptors.
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Side Effects of ergotamines
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alpha ago causes vasoconstriction and uterine contractions
DA ago may cause nausea and vomitting Dependence may develop |
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Administratin of dihydroergotamine
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Intranasal or iv, im
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Contraindications for ergotamines
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Pregnancy
Peripheral vascular disease ischemic HD renal or hepatic disease |
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Methylsergide
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3rd line migrain b/c can cause inflammatory fibrosis. drug holidays needed
metabolite is setonergic and alpha 1 agonist |
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"Other" migrain drugs
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NSAIDS, acetomenophen, propranolol, amitriptyline, Valproate, and butalbital
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