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10 Cards in this Set

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Sumatriptan
Serotonin analog that activates 5-HT receptors in brain to constrict vessles and reduce production of inflammatory substances

Reduces headaches, nausea/vomiting, pain
Side Effects of Sumatriptan
May effect coronary circulation
Second generation triptans
high BBB penetrance and more effective
First dosing of sumatriptan
Give in physicians office to monitor for Printzmetal's angina
Ergotamine and dihydroergotamine
Older migraine drugs that activate serotonin, DA and alpha adrenergic receptors.
Side Effects of ergotamines
alpha ago causes vasoconstriction and uterine contractions
DA ago may cause nausea and vomitting
Dependence may develop
Administratin of dihydroergotamine
Intranasal or iv, im
Contraindications for ergotamines
Pregnancy
Peripheral vascular disease
ischemic HD
renal or hepatic disease
Methylsergide
3rd line migrain b/c can cause inflammatory fibrosis. drug holidays needed

metabolite is setonergic and alpha 1 agonist
"Other" migrain drugs
NSAIDS, acetomenophen, propranolol, amitriptyline, Valproate, and butalbital