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13 Cards in this Set
- Front
- Back
International Headache Society Classification: Primary Headache
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-Tension headache
-Cluster headaches -Migraine headaches |
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International Headache Society Classification: Secondary Headache
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-Organic disorders:
-Hemorrhage -Infection -Stroke -Tumor |
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Primary Headache: Tension headache
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-bilateral
-band-like pressure -dental, cervical, visual corrections |
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Primary Headace: Cluster headaches
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-unilateral
-behind eye -15 min to 3 hrs -0.5% of population |
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Migraine: Elements (?)
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-Triggers (stress, anxiety, hormones, chocolate)
-Disorder of cranial blood vessels -Involvement of 5HT and/or NE -May involve glutamate, NO, histamine sensitivities -Trigeminal nerve (V) sensory afferents |
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Migraine: Phases
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-Premonitory
-Aura -Headache -Postdrome |
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Migraine: Premonitory phase
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-60%
-hrs/days -psychological, sensory or autonomic |
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Migraine: Aura phase
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-20%
-visual, sensory, motor, language disturbances |
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Migraine: Headache phase
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-4 to 72 hrs
-photophobia, phonophobia, sensory stimulation |
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Migraine: Postdrome phase
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-up to 24 hrs
-euphoric, depressed, irritability |
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Migraine: Neurogenic model
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-neuronal dysfunction w/subsequent vascular changes
-release of vasoactive neuropeptides: -Sub P -Calcitonin gene related peptide -Neurokinin A causing vasodilation -Plasma extravasation -Mast cell degranulation -Neurogenic inflammation -Ascending projections of trigeminal nerve activate thalamic pain centers -Facial nerve (VII) activated |
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Migraine: Acute treatment (Mild to Moderate)
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-Oral analgesics (Aspirin, NSAIDS, Acetaminophen)
-Ketorolac: -stronger NSAID -IM or oral -decrease pain, nausea, photophobia -Antiemetic agents -chloropromazine -metoclopromide -promethazine |
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Migraine: Actue treatment (Moderate to Severe)
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-Ergots
-vasoconstrictors -Ergotamine tartrate (oral or suppository) -Dihydroergotamine (IM or nasal spray) -Triptans -Opiates -MOA: -activate 5HT 1D/1B -activate presynaptic 5HT 1D/1B receptors |