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54 Cards in this Set
- Front
- Back
Describe the gram stain for streptococcus
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They are gram positive. They are spherical or ovoid in shape and tend to grow in pairs or chains.
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Are streptococci motile or nonmotile? spore forming or nonspore forming?
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They are nonmotile, nonspore forming
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Describe the need for air of streptococci
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They are facultatively anaerobic
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What are the most important streptococcus pathogens?
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Streptococcus pyogenes (group A streptococcus), Streptococcus agalactiae (group B streptococcus), and Streptococcus pneumoniae (pneumococcus)
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What is the other name for group A streptococcus?
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Streptococcus pyogenes
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What is the other name for group B streptococcus?
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Streptococcus agalactiae
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What is the other name for pneumococcus?
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Streptococcus pneumoniae
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What group used to be part of streptococci?
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Enterococci
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What are the sites of colonization of S. pneumoniae?
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Oropharynx, nose
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What are the sites of colonization of S. pyogenes?
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Nares, pharynx, rectum
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What are the sites of colonization of Enterococcus faecalis and faecium?
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GI tract
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What are the sites of colonization of S. agalactiae?
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GU tract
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What are the sites of colonization of Viridans streptococcus?
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Oropharynx
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What bacteria species colonize the oropharynx?
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S. pneumoniae, Viridans streptococcus
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What bacteria species colonize the nose?
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S. pneumoniae
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What bacteria species colonize the nares?
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S. pyogenes
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What bacteria species colonize the pharynx?
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S. pyogenes
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What bacteria species colonize the rectum?
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S. pyogenes
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What bacteria species colonize the GI tract?
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Enterococcus faecalis and faecium
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What bacteria species colonize the GU tract?
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S. agalactiae
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What are the common sites of infection for S. pneumoniae?
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lungs, sinuses, middle ear,
meninges |
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What are the common sites of infection for S. pyogenes?
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pharynx, skin, soft tissue
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What are the common sites of infection for Enterococcus faecalis and faecium?
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urinary tract, biliary tract,
peritoneum, heart valves |
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What are the common sites of infection for S. agalactiae?
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neonatal, bloodstream, lung and
meninges. genitourinary tract |
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What are the common sites of infection for Viridans streptococcus?
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dental caries, heart valves,
bloodstream |
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What bacteria often infect the lungs?
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S. pneumoniae, S. agalactiae
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What bacteria often infect the middle ear?
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S. pneumoniae
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What bacteria often infect the meninges?
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S. pneumoniae, S. agalactiae
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What bacteria often infect the pharynx?
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S. pyogenes
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What bacteria often infect the skin?
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S. pyogenes
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What bacteria often infect soft tissue?
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S. pyogenes
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What bacteria often infect the GU tract?
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Enterococcus faecalis
and faecium, S. agalactiae |
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What bacteria often infect the biliary tract?
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Enterococcus faecalis
and faecium |
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What bacteria often infect the peritoneum tract?
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Enterococcus faecalis
and faecium |
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What bacteria often infect the heart valves?
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Enterococcus faecalis
and faecium, Viridans streptococcus |
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What bacteria are often responsible for neonatal infections?
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S. agalactiae
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What bacteria infect the bloodstream?
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S. agalactiae, Viridans streptococcus
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What bacteria are associated with dental caries?
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Viridans streptococcus
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How are streptococci classified?
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Through hemolytic pattern or Lancefield grouping
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What is hemolytic typing?
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Hemolytic typing has to do with the type of hemolysing that occurs
alpha - green hemolysis beta - clear hemolysis gamma - no hemolysis |
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What is Lancefield grouping?
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It is based on the cell wall carbohydrate antigens
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Classify S. pneumonia
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Optochin disk: S
Bacitracin disk: R Growth in 6.5% NaCl: - Hydrolyze Bile-Esculin: - Hippurate hydrolysis: - |
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Classify S. pyogenes
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Optochin disk: R
Bacitracin disk: S Growth in 6.5% NaCl: - Hydrolyze Bile-Esculin: - Hippurate hydrolysis: - |
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Classify E. faecalis, faecium
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Optochin disk: R
Bacitracin disk: R Growth in 6.5% NaCl: + Hydrolyze Bile-Esculin: + Hippurate hydrolysis: - |
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Classify S. agalactiae
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Optochin disk: R
Bacitracin disk: R Growth in 6.5% NaCl: - Hydrolyze Bile-Esculin: - Hippurate hydrolysis: + |
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Classify Viridans streptococcus
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Optochin disk: R
Bacitracin disk: R Growth in 6.5% NaCl: - Hydrolyze Bile-Esculin: - Hippurate hydrolysis: - |
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What is the outer surface of group A streptococcus made from?
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A hyaluronic acid capsule that interferes with phagocytosis
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What is the M protein? What does it do?
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The M protein is the major virulence factor of group A streptococcus.
The protein interferes with phagocytosis and strains defective in M protein are avirulent. The M proteins appear to promote colonization of tissue surfaces. M proteins are also used to classify GAS based on their variation in structure and sequence. The structure is filamentous and is an alpha-helical coiled-coiled structure. Immunity to infection with GAS is type-specific and is based on the antiphagocytic moiety of the M protein. The antigenically variable regions of the protein are found at the amino terminus and are the most distal. M protein has also been implicated in the pathogenesis of rheumatic fever. |
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What does protein F1 do?
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Together with lipoteichoic acid mediates binding to fibronectin, a host extracellular matrix molecule found on the surface of epithelial cells.
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What does lipoteichoic acid do?
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Together with Protein F1 mediates binding to fibronectin, a host extracellular matrix molecule found on the surface of epithelial cells.
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What does Protein G do?
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It binds to the Fc portion of immunoglobulin (similar to protein A in S. aureus)
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What findings are suggestive of GpA strep? What are not suggestive?
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Suggestive: Sore throat, sudden onset, fever, pain with swallowing, headache, lymphadenitis, tonsillar exudates, soft palate petechiae
Not suggestive: Conjunctivitis, coryza, cough, diarrhea |
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Whats the difference between S. aureas and Strep TSS?
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Strep differs from S. aureus TSS because of the frequent presence of infection.
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What is the pathogenesis of the pneumococcal pneumonia from S. pneumo
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-Adheres to type II cells and initiates immune response
-Cell wall causes inflammatory response -Fluid accumulation-> Congestion -Red hepatization (leakage of RBCs) -Gray hepatization (recruitment of macrophages) -Resolution of pneumonia starts with development of anticapsular antibody |