Mid Diseases I

Front 1

Toxic Shock Syndrome

Back 1

-Toxic shock syndrome toxin 1 (TSST-1), an exotoxin, is from S. aureus
-From superabsorbant tampons, surgery, or sutures
-TSST-1 penetrates mucosa and is a potent stimulator of TNF and IL-1
-TSST-1 binds to MHCII molecule outside of binding groove
-High fever, nausea, vomiting, watery diarrhea, followed by diffuse erythematous rash, palm and sole skin peeling
-Can cause septic shock

Front 2

Scalded Skin Syndrome

Back 2

-From exfoliative toxins A and B from S. aureus
-Usually in neonates with local infection of recently severed umbilicus or older children with skin infections
-Causes cleavage of middle epidermis with fine sheets of skin peeling off to reveal moist red skin beneath.

Front 3

Pharyngitis (bacterial)

Back 3

-Caused by S. pyogenes
-Most common of the streptococcal infections
-Fever, lymphadenopathy, swollen, erythematous tonsils
-Self-limited
-Difficult to distinguish from viral pharyngitis
-Serologic assays include anti-streptolysin O (ASO) test
-Most common bacterial infection of the throat in children
-Adhere and are internalized by oropharyngeal epithelial cells

Front 4

Rheumatic Fever

Back 4

-Caused by S. pyogenes
-Nonsuppurative sequela of group A streptococcal infections
-Characterized by carditis, polyarthritis, subcutaneous nodules, chorea, and a skin rash called erythema marginatum
-Diagnose with Jones criteria

Front 5

Pneumonia

Back 5

-Caused by S. pneumoniae
-Sudden onset of fever, chills, pleuritic chest pain, cough, rusty colored sputum
-Lobar infiltrate