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48 Cards in this Set
- Front
- Back
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The major categories of hypersensitivities that typically involve a B cell immunoglobulin response is...
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Type 1/2/3/
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Atopy and anaphylaxis are hypersensitivities in the category;
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Type 1 only
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List 4 factors involved in type 2 hypersensitivity;
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1. IgM
2. IgG 3. complement 4. foreign cells |
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Human blood types involve...
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1. ABO antigen markers
2. inheritance of two of three possible alleles 3. genetically determined 4. genes that code for an enzyme that adds a terminal CHO to RBC receptors. |
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The serum of a person with blood type A, Rh- will have which antibody factor?
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Anti B, anti Rh
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A person with O type blood...
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lacks A and B antigens
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A person who has anti A and anti B serum antibodies will have blood type...
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O blood type
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list 4 results of transfusing the wrong blood type.
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1. recipient antibody activating the complement cascade to attack the RBCs.
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A female who is Rh+...
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is in the majority of the population with regard to Rh status.
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The potential for hemolytic disease of the newborn occurs when...
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fetal Rh+ cells enter an Rh- mother
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Once a mother has been sensitized to the Rh factor...
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all other Rh+ fetuses are at risk
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Bee sting venom is considered to be which type of allergen?
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injectant
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Fungal spores and animal dander are considered to be which type of allergen?
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inhalant
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The initial encounter with an allergen is called the...
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sensitizing dose
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What will be the immediate action of an allergen when it enters the body for a 2nd time?
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bonding of allergen to adjacent IgE binding sites on mast cells and basophils.
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Which event is the process of releasing chemical mediators?
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degranulation
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Which event occurs with the sensitizing dose of allergen?
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binding of IgE by the Fc region to mast cells and basophils.
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List 4 symptoms of type 1 hypersensitivity?
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rhinitis
rashes sneezing contact dermatitis |
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match the following:
a.food allergy b.poison ivy dermatitis c.serum sickness d.transfusion reaction |
a=type 1 hypersensitivity
b=type 4 c=type 3 d=type 2 |
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Any heightened or inappropriate immune response resulting in tissue damage is called...
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hypersensitivity
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List 4 characteristic symptoms of histamine.
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1. constriction of smooth of bronchi
2. relaxes vascular smooth muscle 3. wheal and flare reaction in skin 4. pruritus and headache |
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The chemical mediator that causes prolonged bronchospasm, vascular permeability, and mucus secretion of asthmatic patients is...
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leukotriene
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List 4 reactions associated with IgE and mast cell mediated allergy.
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1. drug allergy
2. eczema 3. anaphylaxis 4. allergic asthma |
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Epinephrine...
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reverses constriction of airways.
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Autoimmunity is typically due to...
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IgM and IgG
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Allergic patients receiving small, controlled injections of specific allergens are undergoing...
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desensitization
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Large quantities of antibodies that react to the second entry of antigen and lead to formation of antigen-antibody complexes occur in...
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serum sickness
delayed hypersensitivity anaphylaxis hemolytic disease of the newborn |
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Autoantibodies cause tissue injury in which diseases?
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rheumatoid arthritis
myasthenia gravis Grave's disease multiple sclerosis |
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Contact dermatitis involves;
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1. a sensitizing and provocative dose
2. allergen entering the skin 3. T lymphocytes secrete inflammatory cytokines 4. itchy papules and blisters |
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When grafted tissue such as bone marrow contains passenger lymphocytes what could result?
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graft versus host
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Hypogammaglobinemia can be a consequence of a genetic deficiency in B cell survival and maturity. TRUE/FALSE
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TRUE.
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The DiGeorge syndrome is the result of...
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congenital absence or immaturity of the thymus gland.
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Severe combined immunodeficiencies(SCIDs) are due to:
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a genetic defect in the development of both T cells and B cells.
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A secondary acquired immunodeficiency is:
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AIDS
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The gene that maintains a normal cell division cycle is...
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tumor suppressor gene
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List 4 oncogenic viruses.
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certain Retroviruses
certain papilloma viruses Epstein Barr virus Hepatitis B virus |
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Allergic reactions to penicillins are considered a__________ hypersensitivity.
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immediate
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Tissue transplanted from one body site on a patient to a different body site on that patient is called an_______
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autograft
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_________ involves determination of donor HLA antigens compared to those of the recipients tissue.
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both a skin graft and an organ transplantation
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Myasthenia gravis disease arises from the production of auyoantibodies against...
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acetylcholine receptors on skeletal muscle
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In multiple sclerosis, autoantibodies attack...
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myelin sheath cells of the nervous system
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Allergies run in families because...
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relative production of IgE is inherited
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During graft rejection, cyto toxic T cells of the recipient recognize and respond to foriegn class 1 MHC receptors receptors on the grafted cells. TRUE/FALSE
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TRUE
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The allergen in poison ivy plants is called urushiol. TRUE/FALSE
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TRUE.
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The most common immunoglobulin deficiency is an IgG deficiency. TRUE/FALSE
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TRUE
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A xenograft is graft tissue from a donor of one species transplanted to a recipient of another species. TRUE/FALSE
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TRUE.
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Eczema is an autoimmune disorder. TRUE/FALSE
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TRUE
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A person who is Rh neg will have anti Rh antibodies in their serum from early infancy. TRUE/FALSE
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TRUE.
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