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9 Cards in this Set

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What diseases does L. PNEUMOPHILA CAUSE?
Legionnaires/Pontiac fever
How does legionnaires disease present?
Severe atypical lobar pneumonia with neurologic and GI(nonbloody diarrhea), hyponatremia.
What are the risk factors for legionnaires disease?
Cigarette smoking, chronic lung disease and immunosuppressed states.
Where is L. pneumophila found within infected patients? Why?
Intracellularly in alveolar monocytes/macrophages. It is a facultative intracellular organism that inhibits phagosome lysosomal fusion and replicates within the phagosome.
How is legionnaires disease diagnosed?
Most commonly with culture on selective media(buffered charcoal yeast extract agar), iron and cysteine are required growth factors and urinary antigen test.
What stain is required to visualize legionnaires?
Silver staining or immunoflurescence staining. It stains poorly with Gram stain.
What have been the major sources for legionnaires disease/
Water sources(air conditioners, water distribution systems) due to inhalation of aerosolized particles. person to person transmission does not occur.
What are the treatment options for legionnaires?
Mortality can be from 30-50%. Rapid treatment with macrolids is needed. Azithromycin, erythromycin,
Fluoroquinolones, or tetracyclines.
What are the signs and symptoms of Pontiac fever and how does it differ from legionnaires disease?
Pontiac fever includes generalized headache, fever, chills and myalgias without any respiratory complaints. It is generally self limiting.