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10 Cards in this Set

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  • Back
What diseases are commonly associated with P. aeruginosa?
Pneumonia(cystic fibrosis patients), mechanically ventilated patients, external otitis, diabetics, UTIs, I/V drug users, hot tub folliculitis.
What are some important biochemical characteristics of P. aeruginosa?
Obligate aerobe that grows on blood or MacConkey agar, does not ferment lactose, oxidase positive, produces pyoverdin(green pigment)
How is P. aeruginosa differentiated from Enterobacteriae?
All will grow on MacConkey agar, but P aeruginosa is oxidase positive and lactose negative.
What is the mechanism of exotoxin A produced by P. aeruginosa?
ADP ribosylates elongation factor 2(EF-2) and inhibits protein synthesis.
A toxin produced by which bacteria also inhibit EF-2?
Corynebacteria diphtheria
What two groups of patients are very susceptible to P. aeruginosa?
Burn patients and cystic fibrosis.
What is a common source of P. aeruginosa?
P. aeruginosa is a water loving organism and common sources include hospital respiratory equipment and plants.
Why is P. aeruginosa one of the most feared bacteria?
It is ubiquitous, causes a large variety of diseases, can be very virulent, and is relatively antibiotic resistent.
What is the clinical significance of ecthyma gangrenosum?
An ulcerated lesion with black eschar. It appears almost exclusively in Pseudomonas sepsis, and requires immediate medical attention and antibiotic coverage.
What is the treatment for P. aeruginosa?
Severe infections: Ticarcillin/piperacillin, or cephalosporin(ceftazidime, cefapime, plus an aminoglycoside(gentamicin, tobramycin, amikacin.
Ciprofloxacin(pseudomonas specific fluoroquinolone).