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10 Cards in this Set
- Front
- Back
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What diseases are commonly associated with P. aeruginosa?
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Pneumonia(cystic fibrosis patients), mechanically ventilated patients, external otitis, diabetics, UTIs, I/V drug users, hot tub folliculitis.
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What are some important biochemical characteristics of P. aeruginosa?
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Obligate aerobe that grows on blood or MacConkey agar, does not ferment lactose, oxidase positive, produces pyoverdin(green pigment)
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How is P. aeruginosa differentiated from Enterobacteriae?
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All will grow on MacConkey agar, but P aeruginosa is oxidase positive and lactose negative.
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What is the mechanism of exotoxin A produced by P. aeruginosa?
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ADP ribosylates elongation factor 2(EF-2) and inhibits protein synthesis.
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A toxin produced by which bacteria also inhibit EF-2?
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Corynebacteria diphtheria
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What two groups of patients are very susceptible to P. aeruginosa?
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Burn patients and cystic fibrosis.
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What is a common source of P. aeruginosa?
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P. aeruginosa is a water loving organism and common sources include hospital respiratory equipment and plants.
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Why is P. aeruginosa one of the most feared bacteria?
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It is ubiquitous, causes a large variety of diseases, can be very virulent, and is relatively antibiotic resistent.
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What is the clinical significance of ecthyma gangrenosum?
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An ulcerated lesion with black eschar. It appears almost exclusively in Pseudomonas sepsis, and requires immediate medical attention and antibiotic coverage.
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What is the treatment for P. aeruginosa?
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Severe infections: Ticarcillin/piperacillin, or cephalosporin(ceftazidime, cefapime, plus an aminoglycoside(gentamicin, tobramycin, amikacin.
Ciprofloxacin(pseudomonas specific fluoroquinolone). |
