Microreview137A(Invasive Bacterial Diarrhea)

Front 1

What is the classic symptom of diarrhea caused by organisms that invade the enteric mucosa?

Back 1

Bloody diarrhea

Front 2

What are the 4 maqin bacterial causes of bloody diarrhea?

Back 2

Shigella
Salmonella
Campylobacter
E. colio157:H7

Front 3

Of the 4 major causes of invasive diarrhea, which 2 do not ferment lactose?

Back 3

Shigella and Salmonella

Front 4

What are some other bacteria that can cause a bloody diarrhea/

Back 4

Yersinia enterocolitica
Vibrioparahemolyticus
Bacillus anthracis(rare)

Front 5

What does methylene blue staining indicate?

Back 5

Leukocytes are present in the stool. This indicates an invasive organism(Shigella, Salmonella, Campylobacter, E. coli 0157:H7), and not one of the toxin producing organisms(except C. difficile).

Front 6

Which curved G- rod causes a bloody diarrhea and is associated with Guillian-Barre' syndrome?

Back 6

C. jejuni

Front 7

Which is the most common cause of diarrhea worldwide?

Back 7

Campylobacter

Front 8

What is the reservoir for C. jejuni?

Back 8

Domestic animals such as dogs, cattle and chickens.

Front 9

What is the clinical course of the disease?

Back 9

Usually causes enterocolitis with initial watery stools, then lower abdominal pain, bloody mucopurulent diarrhea, and fever. Symptoms usually resolve in 7 days.

Front 10

What autoimmune diseases can develop subsequent to GI infection with Campylobacter?

Back 10

Guillian-Barre' syndrome, Reiter's syndrome, and reactive arthritis.

Front 11

How is alab diagnosis made?

Back 11

C. jejuni must be grown under special conditions to select for it. Namely, a blood agar and antibiotic coupled with a temperature of 42C and an atmosphere of 10% CO2 and 5% O2.

Front 12

What is the treatment for C. jejuni diarrhea?

Back 12

Ciprofloxacin or erythromycin can both be given to shorten the duration of symptoms and to prevent the spread of disease to others.

Front 13

Does Shigella have a high or low ID50?

Back 13

Very low. Just a hundred organisms can cause disease.

Front 14

There is no animal reservoir for Shigella, it only infects humans. TRUE/FALSE

Back 14

TRUE

Front 15

Does Shigella cause disease through toxin production or neteroinvasion of the mucosa?

Back 15

Through invasion of the mucosa. Mutated starins without the Shiga toxin still cause disease but mutated starins that cannot invade do not cause disease.