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10 Cards in this Set
- Front
- Back
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Which drugs are commonly used to treat Mycobacterium tbc infection?
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(ERIP) Ethambutol
Rifampin Isoniazid Pyrazinamide |
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What is the mechanism of action of ethambutol and is its unique side effect?
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Inhibits arabinosyl transferase, an enzyme necessary to make the mycobacterial cell wall. Also causes decreased visual acuity and color vision.
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What is the mechanism of action of rifampin?
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Inhibits DNA-dependent RNA polymerase by binding to RNA polymerase and blocking elongation of RNA.
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What are common indications for Rifampin/
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M. tbc/N. meningitidis(prophylaxis)/H. influenzae
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Why shouldnt Rifampin be used as monotherapy?
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Resistance occurs rapidly. However, it may be used monotherapeutically for N. meninggitidis and H. influenzae.
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What are some common side effects of Rifampin?
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Red orange urine, induces P450, GI symptoms, headache, fever, rash.
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What is the mechanism of action of INH?
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It is thought to inhibit , mycolic acid synthesis.
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What are some side effects of INH?
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Hepatotoxicity(avoid alcohol) peripheral neuropathy(vit B6 depletion) sideroblastic anemia(B6 depletion).
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Name 3 drugs commonly used in the treatment of Leprosy?
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Dapsone/Rifampin/Clofazimine.
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Methmoglobinemia occurs when the Ferrous(Fe2+) form of iron in hemoglobin is oxidized to the Ferric(Fe3+) form and cannot bind O2. What are the clinical manifestations of Methmoglobinemia.
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Dyspnea, headaches, dizziness, altered mentation with cyanosis of extremities and darkened blood. It is treated with Methylene blue.
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