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9 Cards in this Set

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Name 2 antibiotics that inhibit bacterial growth by acting as p-aminobenzoic acid(PABA) analogs.
Sulfanamides and Dapsone
Which enzyme in bacterial folate syntheisi is inhibited by Sulfonamides?
Dihydropteroate synthetase
Can bacteria obtain folic acid by diffusion or active transport?
No. Bacteria must synthesize folic acid from PABA.
What is the risk of giving sulfonamides during pregnancy?
Sulfanamides can displace bilirubin from plasma albumin binding sites and induce kernicterus in the newborn.
What are some other side efects of sulfonamides?
Induce hemolysis in glucose-6- phosphate dehydrogenase(C6PD)-deficient patients, photosensitivity and hypersensitivities.
What is the mechanism of action of Trimethoprim?
Inhibits bacterial dihydrofolate reductase.
What are important side effects of Trimethoprim?
megaloblastic anemia, leukopaenia and granulocytopaenia. Alleviate these symptoms with supplemental folinic acid.
What is the drug of choice for treating simple recurrent UTIs?
Trimethoprim-Sulfamethoxazole(TMP-SMX)
List 6 antibacterial targets.
1. Peptidoglcan cell wall(b-lactams/non beta(vancomycin, bacitracin, fosfomycin, cyclosporine)
2. Electron transport proteins(Metronidazole)
3. 30S ribosome subunit(aminoglycosides)
4. 50S ribosome subunit(Caf, macrolides,Clindamicin)
5. PABA
6. Folic acid synthesis(sulfanamides, TMP)
7. DNA gyrase and topoisomerase(quinolones)