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12 Cards in this Set
- Front
- Back
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What are the three main effects of complement?
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1. Lysis of cells
2. Generation of mediators 3. Opsonization |
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Which of the complement pathways react the first time we are infected with a microrganism?
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Alternative and Lectin (innate immunity) Antibody for the classical pathway is not present the first time
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All three pathways lead to the production of ____ the central molecule.
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C3b
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What are the two main roles of C3b
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1. Opsonization - phagocytes have C3b receptors
2. Combines to form C5 convertase which leads to production of MAC |
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What are the two complexes that make up a C3 convertase?
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C4b,2b and C3b,Bb
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What makes up the membrane attack complex?
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C5b,6,7,8,9
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Which complement pathway resembles the classical pathway but bypasses the antigen binding step?
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The MBL (Lectin) pathway
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What role does factor D play in the alternative pathway?
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Cleaves C3(H2O) and B to form C3b,Bb (C3 convertase)
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What are the two C5 convertases?
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C4b,2b,3b and C3b,Bb,C3b
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This is the most potent anaphylaxotoxin
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C5a
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C3a, C4a and C5a all cause what?
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Degraulation of mast cells - which increases vascular permeability and smooth muslce contraction
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A glycoprotein on the surface of human cells that destabilized C3 and C5 convertase and prevents formation of the MAC.
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DAF- decay accelerating factor
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