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19 Cards in this Set
- Front
- Back
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A 50 yo presents with sudden onset of burning pain in band-like area of skin on back that has vesicles. She has no fever but noticed the lesions turning purple. What might she have?
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VZV
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How are the rashes of VZV characterized?
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2-3 mm vesicles with hemorrhagic base. Some crust over
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What family is VZV a member of?
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herpesvirus
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How is VZV characterized?
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enveloped, dsDNA
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How many serotypes of VZV are there?
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1
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Can VZV be cultured?
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yes
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How can a presumptive identification of VZV be made in culture?
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characteristic appearance of eosinophilic intranuclear inclusions and multinucleated giant cells in infected fetal diploid kidney cells
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How is chickenpox characterized?
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sudden onset of fever, and skin maculopapular erruption for a few hours progressing to vesicular then pustular in 3-4 days and then crusting. Note that vesicles collapse on puncture
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Where are chickenpox lesions most numerous?
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scalp, axilla and mucus membranes of mouth and upper respiratory tract
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what seasons does chickenpox tend to occur most?
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late winter and early spring in temperate climate
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How is VZV transmitted? Why is it so contagious?
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airborne transmission 1-2 days before onset of rash so people don't know they even have it
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When does shingles typically occur?
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people over 50
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How does VZV spread to the skin?
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hematogenously
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Where does VZV become dormant?
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dorsal root ganglia in sensory nerve roots
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In someone with shingles what can be seen at the base of the skin lesion?
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multinucleated giant cells with intranuclear inclusions
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Where can VZV spread in an immunocompromised person?
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hematogenously goes to lung and causes pneumonia and goes to CNS cuasing encephalitis
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What is the first most common viral cause of Reyes syndrome in children? what is second?
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1) influenza B
2) VZV |
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What is used to treat VZV and Zoster?
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acyclovir
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What antibody is produced to the VZV vaccine?
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IgG
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