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16 Cards in this Set
- Front
- Back
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A 2 yo with slight fever, swollen lymph nodes and rash presents. He has no immunizations and PE shows diffuse maculopapular rash. What might he have?
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Rubella virus
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What else is Rubella virus known as?
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German measles
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Are patients usually sicker with rubella or rubeola?
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rubeola
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What family does Rubella virus belong to?
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togavirus
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what are the characteristics of Rubella virus?
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enveloped, incosehedral nucleocapsid, ssRNA
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What surface proteins does Rubella virus have?
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hemagglutinin
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How many serotypes of Rubella virus are there?
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1
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Where can Rubella virus be cultivated from?
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throat, nasopharynx, urine
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What is the risk of woman contracting Rubella virus?
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if she gets pregnant Rubella virus can cause congenital defects
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Where does Rubella virus initially infect? where does it spread?
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1) nasopharynx and lung epithelium
2) spreads hematogenously to lymphatics and reticuloendothelial |
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How many days after initial infection with Rubella virus does secondary viremia occur? What happens?
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6-20 days after initial infection virus spreads to demal capillary endothelial cells where T cells attack them
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What does rash follow in Rubella virus infection? How long does it last
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prodromic febrile stage and lasts 3 days (rash is after fever)
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What type of hypersensitivity does Rubella virus initiate?
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type III and IV
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What does the Rubella virus vaccine initiate?
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induces a respiratory IgA response which interrupts the spread of virulent virus by nasal carriage
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What trimester is most susceptible to Rubella virus?
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1st
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What would confirm if a child had rubella during the fetal period?
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presence of specific IgM 2 weeks to 3 months after birth
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