Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
An 18 yo presents with fever, headache and progressive dry cough for 2 weeks; however, in the past day small amounts of clear sputum appeared. PE shows tachypnea, pharyngeal erythema, cervical adenopathy and low Hct. X- ray show B/L patchy infiltrates. What do you suspect?
|
M pneumoniae
|
|
|
How is M pneumoniae different from other types of atypical pneumonia?
|
clinical pulmonary findings are often absent
|
|
|
What symptoms are associated with Legionella that are not seen with M pneumoniae?
|
GI symptoms and severe headache
|
|
|
What else is M pneumoniae known as?
|
walking pneumonia or primary atypical
|
|
|
What are the smallest free living self replicating organisms?
|
mycoplasms
|
|
|
What are the characteristics of M pneumoniae?
|
wall less bacteria containing a 3 layer plasma membrane the outer layer contains cholesterol, do not react with gram stain,
|
|
|
How long may it take to grow M pneumoniae?
|
6 weeks
|
|
|
What are the most important features that aid in diagnosis of atypical pneumonia?
|
1) nonproductive cough
2) variable chest x ray (patchy, diffuse infiltrates) 3) no bacteria on smear 4) no response to beta-lactam antibiotics |
|
|
What is a useful confirmation of M pneumoniae infection? What are not useful techniques?
|
do not use gram stain or cultures
use micro-organism specific IgG antibody response |
|
|
Does M pneumoniae cause both upper and lower respiratory tract infections?
|
yes
|
|
|
What age groups is M pneumoniae infection common in?
|
5-20 year olds
|
|
|
What is a major mode of transmitting M pneumoniae?
|
person to person
|
|
|
What is the appearance of M pneumoniae?
|
filamentous tips (flask-shaped) that are complex composed of adhesins, and adherence accessory proteins
|
|
|
Where do M pneumoniae colonize? What results
|
between cilia impairing their movement and prolonging cough
|
|
|
What toxic molecule do M pneumoniae produce to damage cells?
|
H2O2
|
|
|
M pneumoniae induces the production of what antibody? What happens?
|
IgM autoantibodies that react with a variety of host tissues, including antigen I on RBCs.
|
|
|
What is used to treat M pneumoniae?
|
erythromycin or doxycycline, may use clarithromycin or azithromycin, or levofloxacin
|
|
|
What is a common syndrome that occurs with M pneumoniae?
|
tracheobronchitis
|
|
|
What are less common complications of M pneumoniae?
|
ARDS, myocarditis, hemolytic anemia, encephalitis
|
|
|
Young males infected with M pneumoniae are prone to what?
|
erythema multiform which in its more severe form may progress to Steven Johnson syndrome
|
|
|
What groups does M pneumoniae occasionally cause death in?
|
elderly and SCD
|
