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35 Cards in this Set
- Front
- Back
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What are the 6 types of PTs that are the most likely to get fungal infections?
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Cancer
Transplants AIDS autoimmune diabetes long-term hospital |
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What are the 6 specific risk factors for fungal infections?
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Broad spectrum antibiotics
radiation chemotherapy corticosteroids surgery catheterization |
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What kind of cell structure do mycosis have?
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these have eurkaryotic cell structure
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what two things are found in fungal cell membranes?
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Ergosterol and Zymosterol
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What 3 things make up fungal cell walls?
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Chitin
Beta Glucan Mannan |
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what does yeast look like under a microscope?
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an oval fungal cell with budding
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what is pesudohypha?
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this is a string of elongated yeast cells in a chain. looks like sausage links
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What is the characteristic of Histoplasma capsulatum in macrophages?
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these will be budding yeasts inside the macrophages
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What bug should you think of when you hear the term 'encapsulated yeast'?
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Cryptococcus
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what makes up the capsule of crytococcus?
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polysaccharides
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what fungus is strongly associated with pseudohypha?
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candida albicans
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what fungus is strongly associated with a germ tube?
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candida albicans
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what is the function of a germ tube?
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this is a virulence factor- allows for attachment ad penetrate into tissue via proteases
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What is a hypha?
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this is a long strand or filament of cells-
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What kind of hyphae does Aspergillus have?
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septate hyphae
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What two fungi have non septate hyphae?
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rhizopus and mucor
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what disease are rhizopus and mucor associated with?
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diabetes
(non septate hyphae, diabetic) |
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What is a sporangium?
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this is the sack like structure that contains the sporangiospore
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What is a sporangispore?
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this is the small reproductive unit (asexual)
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what type of reproductive structures do Rhizopus and Mucor have?
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these have sporagnium, and sproangiospores
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What type of reproductive structures do penicillium and aspergillus have
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these both have conidium (asexual)
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What is a Conidia?
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this is a spore
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What is an Arthrocondium?
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this is a jointed (arthus) or fragmented hypha
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what are chlamydospores?
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these are used to sustain a colony in difficult environments (survival propigiles)
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What groups of people usually get muscal infections of candidia?
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immunosuppressed, contraceptive, antibiotics
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what goups of people usually get skin infections of candida?
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elderly and obese
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what is paronychia?
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a nail infection of candida
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what group of people usually get systemic candidiasis?
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respiratory and urinary tract infections can lead to candidemia
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What are the two common media used to grow fungus?
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sabouraud agar
potato dextrose agar |
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What does Ketoconazole-itraconazole do?
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this inhibits ergosterol synthesis
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what does amphotericin B do?
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this targets ergosterol- damaging membrane
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what does Griseofluvin do?
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this interferes with mitosis
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What does flucytosine do?
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this interferes with DNA and protein synthesis
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what does Terbinafine do?
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this inhibits ergosterol synthesis
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what does caspofungin do?
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this inhibits glycan wall synthesis (Candida and Aspergillus)
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