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14 Cards in this Set
- Front
- Back
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what genus does it belong to? what family?
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1) hepacivirus
2) flaviviridae |
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What type of genome and structure does HCV have?
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enveloped icosahedral capsid with a polyadenylated +ssRNA genome
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What genotype is the most common in the US?
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1
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HCV is referred to having quasispecies what are these?
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different species of HCV that are distinguished only by a few nucleotide differences
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How is HCV different from HBV in relation to host immunity?
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unlike HBV infection with one serotype of HCV does not convey resistance to all serotypes of HCV
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In the US what is the major mode of transmission?
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parenteral via drug use, also permucosal, and perinatal occur, sexual transmission is possible
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What is the incubation period?
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14-180 days or average 6-7 weeks
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Are 80% of people are symptomatic or asymptomatic?
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asymptomatic
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What is the most characteristic feature?
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elevated ALT levels and precede anti-HCV seroconversion
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In most people ALT levels normalize, what generally happens?
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they rise again indicating progression to chronic disease
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When liver enzymes fluctuate between high and low values what does it indicate?
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active liver disease
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What are good tests to determine HCV infection?
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HCVab and RT-PCR
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Can HCVab be used to differentiate acute vs chronic infection?
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no
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what is the treatment?
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interferon and ribavirin
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