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6 Cards in this Set
- Front
- Back
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Neisseria species: bacterial characteristics?
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gram-negative
diplococci (donut shaped) oxidase positive |
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N. Meningitidis: virulence factors?
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Capsule
Endotoxin (LPS) Pili (adhesins) IgA protease outer membrane protein |
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N. Meningitidis: transmission?
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spreads via respiratory secretions
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N. Meningitidis: clinical manifestations?
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-petechial rash(classic clue)
Meningococcemia- spiking fevers, chills, joint pain, muscle pain Fulminant meningococcemia (Waterhouse-Friedrich syndrome)- septic shock; hemmorrhage to adrenal glands, adrenal insufficiency Meningitis |
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N. Meningitidis: immunity?
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-0 to 6 mo.: passively immune
-6 mo. to 2yr: highly susceptible -adults: most have antibodies higly susceptible: those that are asplenic and those w/ complement deficiencies |
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N. Meningitidis: vaccine and Rx?
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vaccine
contains capsular antigens used in military & international travelers Rx Penicillin (but, doesn't cure carriers) Prophylaxis 4 close contacts: rifampin, ciprofloxacin, ceftriaxone |
