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30 Cards in this Set

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Normal Microbial Flora

Microorganisms usually found on/in human body

Dental Plaque

Extensive growth on tooth surface

Streptococcus pyogenes

Causative agent of "Strep throat"

Corynebacterium diphtheriae

Causes "Diphtheria"


- Stalls protein synthesis


- Severe respiratory disease

Streptococcus pneumoniae

Causes "pneumonia "

Bordetella pertussis

Causative agent of "Whooping cough"


- Pertussis is caused by this microbe

Herd Immunity

If a high proportion of individuals are immune to an infectious disease, than the whole population is protected.

Common Cold

Colds are caused by Viruses


- Most common infectious disease.

Influenza

Caused by orthomyxoviruses

Antigen Drift

Minor changes in influenza virus antigens due to gene mutation (& selection/genetic drift)

Antigenic Shift

Major changes in influenza virus antigens due to gene reassortment

Staphylococcus

Non-sporulating facultatively aerobic, gram-positive cocci

Helicobacter pylori

Colonized mucosa of stomach & upper intestinal tract.

Neisseria gonnorrhoeae

Causative agent of "Gonorrhea"

Treponema pallidum

Causative agent of "Syphilis"

Chlamydia trachomatis

Causative agent of "Chlamydia"


Human immunodeficiency virus

Causative agent of "Acquired immunodeficiency Syndrome (AIDS)"

Cut hunter hypothesis

In the late 1990s, Vial of HIV + blood found in Kinshasa from 1959.


- SIV in chimps

Kaposi's sarcoma

A common nonmicrobial disease, a typical cancer.

Borrelia burgdorferi

Causative agent of "Lyme disease"

Vectored by : Black - legged ticks

Primary mammalian reservoirs

Deer & white-footed mice

Rickettsia

Genus of obligate intracellular pathogens.

- Associated with blood sucking arthropods


- Closely related to the mitochondria

Yersinia pestis

Causative agent of "Plague"

Vectored by fleas

Type III secretion system

Helps resist phagocytic killing and inflammatory immune response

Bubonic plague

Development of buboes on infected individuals.

The Justinian Plague

Began 541 AD, killed >100M

The Black Death

1346-1353, Spread to the whole Europe, Asia, & North Africa killed ~25M in Europe and ~25M in Asia

Borrelia burgdorferi

Causative agent of "Lyme disease"


- Vectored by : Black legged ticks


- Otzi the Iceman has Lyme disease

Rickettsia prowazekii

Causative agent of "Typhus"


- Vectored by "Lice"

Yersinia pestis

Causative agent of "Plague"


- Vectored by Fleas


- Contains type 3 secretion system