Microbiology: Exotoxins

Front 1

S. aureus superantigens (x3)

Back 1

TSST-1 superantigen causes toxic shock syndrome (fever,rash,shock).

enterotoxins that cause food poisoning

exfoliatin, which causes stappylococcal scalded skin syndrome.

Hint 1

Superantigen- Bind directly to MHC II and T-cell receptor simultaneously, activation large numbers of T cells to stimulate release of IFN-Gamma and IL-2

Front 2

S. pyogenes

Back 2

Scarlet fever--Erythrogenic toxin causes toxic shock-like syndrome

Hint 2

Superantigen- Bind directly to MCH II and T-cell receptor simultaneously, activation large numbers of T cells to stimulate release of IFN-Gamma and IL-2

Front 3

Corynebacterium diphtheriae*

Back 3

INACTIVATES EF-2

Hint 3

ALSO Psudomonas

ADP ribosylating - Interfere with host cell function. B (binding) component binds to a receptor on surface of host cell, enabling endocytosis. A (active component then attaches an ADP-ribosyl to a host cell protein (ADP ribosylation), altering protein function.

Front 4

Vibrio cholerae

Back 4

ADP ribosylation of G protein stimulated adenylyl cyclase; increase efflux of Cl- into gut and decrease Na absorption. Volumous rice water stool

Hint 4

ADP ribosylating - Interfere with host cell function. B (binding) component binds to a receptor on surface of host cell, enabling endocytosis. A (active component then attaches an ADP-ribosyl to a host cell protein (ADP ribosylation), altering protein function.

Front 5

E coli (x2)

Back 5

Heat labile toxin - stimulates Adenylate cyclase

Heat stable - stimulates Guanylate cyclase.

Hint 5

ADP ribosylating - Interfere with host cell function. B (binding) component binds to a receptor on surface of host cell, enabling endocytosis. A (active component then attaches an ADP-ribosyl to a host cell protein (ADP ribosylation), altering protein function.

Front 6

Bordetella pertussis

Back 6

Increases cAMP by INHIBITING G(alpha)i.

Causes whooping cough; inhibits chemokine recptor, causing lymphocytosis

Hint 6

ADP ribosylating - Interfere with host cell function. B (binding) component binds to a receptor on surface of host cell, enabling endocytosis. A (active component then attaches an ADP-ribosyl to a host cell protein (ADP ribosylation), altering protein function.

Front 7

Clostridium perfingens

Back 7

alpha toxin causes gas gangrene, (double zone of hemolysis on blood agar)

Front 8

C. tetani

Back 8

Blocks the release of inhibitory neurotransmitters GABA and glycine; Lockjaw

Front 9

C. botulinum

Back 9

Blocks the release of acetylcholine; causes anticholinergic symptoms, CNS paralysis, esp cranial nerves;

Spores found in canned food, honey (floppy baby syndrome)

Front 10

Bacillus anthracis

Back 10

Edema factor, part of the toxin complex, IS AN adenylate cyclase

Front 11

Shigella

Back 11

Shiga toxin cleaves host cell rRNA (inactivates 60S ribosome); also enhances cytokine release, causing HUS

Front 12

S. pyogenes

Back 12

Streptolysin O is a hemolysin; antigen for ASO antibody, which is used in the diagnosis or rheumatic fever.